功能性消化不良辅以艾司西酞普兰联合坦度螺酮临床疗效研究

Efficacy of venlafaxine combined with olanzapine in the treatment of functional dyspepsia complicated with mental symptoms

[目的]研究有精神症状的功能性消化不良FD患者辅以艾司西酞普兰及艾司西肽普兰联合坦度螺酮的临床疗效对照。[方法]选取2017-10-2018-04期间就诊的FD患者100例,分观察组、对照组各50例,对照组行常规药物治疗辅以艾司西酞普兰,观察组在对照组治疗基础上再辅加坦度螺酮,疗程8周,消化道症状以GSRS积分,精神症状以HAMD评分指标观察。[结果]治疗后GSRS积分,观察组减分率为80.98%,对照组减分率为27.37%;治疗后HAMD评分,观察组减分率为50.35%,对照组减分率为27.93%,观察组疗效优于对照组,2组比较差异有统计学意义(P<0.05)。[结论]有精神症状的FD者,采用辅以艾司西酞普兰联合坦度螺酮疗效优于单辅艾司西肽普兰。

[Objective]To investigate the clinical efficacy of escitalopram and escitalopram combined with tamsulosine in functional dyspepsia(FD)patients with psychotic symptoms.[Methods]One hundred FD patients who were treated during October 2017 to April 2018 were involved in the study and were randomly divided into control group and observation group.The control group was treated with routine medicine therapy with escitalopram and the observation group was treated with tanodopirone on the basis of control group.The treatment period was 8 weeks,GSRS points,HAMD scores in all patients were observed.[Results]In GSRS scores,the observation group had a reduction rate of 80.98% after treatment,and the control group had a reduction rate of 27.37%.The HAMD score was 50.35%in the observation group and 27.93% in the control group.The observation group had higher efficacy than the control group.The difference between the two groups was statistically significant(P<0.05)[Conclusion]Escitalopram with escitalopram is more effective than tamsulosin in the treatment of the FD patients with psychotic symptoms.