摘要
目的了解不同变率和时程的电流刺激下神经元的放电情况。方法在经典的H H神经元模型上 ,用不同频率和振幅的正弦电流作为刺激信号 ,仿真研究神经元的放电情况。结果正弦电流刺激在很大的频率范围内可以引发神经元的阵发放电 ,特别是足够强的超低频正弦电流刺激可引起神经元的长时程阵发放电。结论变率很小的电流刺激可以引发神经元的长时程阵发放电 ,这是对传统的神经元适应性观点的补充。同时也说明了强度大的慢突触后电位不仅仅具有对突触功效调节的作用 ,也是神经元超常兴奋的原因之一 ,或许还是某些疾病或神经功能紊乱 (如癫痫 )的电生理机制所在。
Objective To find out the discharge patterns of neurons stimulated by sinusoidal currents with different gradient and time course. Method Discharge of neurons was investigated by simulation method basing on the classical H H model. The stimulus is sinusoidal current with different frequencies and amplitudes. Result Bursting can be induced by sinusoidal current stimulation in a wide range of frequency. In particular, long time course bursting can be induced by sinusoidal current with an ultralow frequency. Conclusion Long time course bursting can be induced by current stimulation with very small gradient, which is a complementarity to the traditional accommodation of neurons. At the same time, it suggests that slow EPSP/EPSC with enough intensity is not only a modulation to synaptic efficacy but is also one of the reasons of neurons , supernormal excitability. It might be the electrophysiological mechanism of some diseases or neuropathic function disorders, such as epilepsy.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2002年第2期108-111,共4页
Space Medicine & Medical Engineering
基金
国家自然科学基金资助项目 (3 990 0 0 3 7)
