期刊文献+

第2代组胺H_1受体阻断药心脏不良反应的浅析与防范 被引量:6

Analysis and countermeasures of cardiotoxicity in association with second generation H1 - receptor blockers
原文传递
导出
摘要 环境污染的加剧,导致过敏反应相应地增加,由此引伸对第2代组胺H_1受体阻断药开发的日趋重视,新药不断上市,其作用强而持久,对中枢和植物神经系统的不良反应甚微,但部分药物对心脏的毒性却日益突出,过量或同时并用肝酶P450抑制剂偶可出现严重的心律失常(尖端扭转型室性心动过速)。为此,对其产生心脏毒性原因及合理应用问题进行探讨,以寻求应用时的防范措施。
机构地区 北京积水潭医院
出处 《药物不良反应杂志》 2002年第2期76-80,共5页 Adverse Drug Reactions Journal
  • 相关文献

参考文献22

  • 1USP.USP dictionary of USAN and international drug names. New York: American Medical Asociation. 1998,355.
  • 2Simons FER.Mizolastine: antihistamine activity from preclinical date to clinical evaluation. Clin Exp Allergy, 1999,29 (Suppl 1): 1.
  • 3Prakash A, Lamb HM. Mizolastine: a review of its use in allergic rhinitis and chronic idopathic urticaria. Biodrug,1998, 10: 42.
  • 4Wedi B, Novacovic M, Koerner M, et al.Chronic urticaria serum induces histamine release, leukotriene production, and basophil CD63 surface expression- inhibitory effects of anti - inflammatory drugs. J Allergy Clin Immunol, 2000, 105: 5521.
  • 5Slater JW, Zechnich AD, Haxby DG.Second generation antihistamines. Drugs, 1999, 57 (1): 31.
  • 6祝宏,张彤.抗变态反应药物研制进展[J].中国新药杂志,2000,9(10):670-672. 被引量:9
  • 7Camphall AM, Crampette L, Lebal B, et al. In vitro inhibition of PGD2 and LTC4 release from human nasal polyp cells by ebastine and care bastine. Allergy, 1995, 26(suppl 1): 194.
  • 8Eda R, Sugiyama H, Hopp RJ, et al.Effect of loratadine on human eosinephil function in vitro. Ann Allergy,1993, 71: 373.
  • 9Michel L, Dubertret L, Jean- Louis F, et al. Modulation of IgE - dependent hypersensitivity reaction by mizolastine: inhibition of antigen- induced soluble ICAM - 1release. J Invest Dermatol, 1997, 108: 822.
  • 10Lindquist M, Edwards IR.Risk of nonsedating antihistamines. Lancet, 1997, 394: 1322.

二级参考文献24

  • 1王贤才(译).临床药物大典[M].青岛:青岛出版社,1994.248-300.
  • 2陈新谦 金有豫.新编药物学,第14版[M].北京:人民卫生出版社,1997.317-318.
  • 3范存忠.特非那定与伊曲康唑合用致尖端扭转型心动过速1例[J].中国循环杂志,1998,13(2):116-116.
  • 4[13]Ko CM,Ducic I, Fan J, et al. Suppression of mammalian K + channelfamily by ebastine[J]. Pharmacol Exp Ther, 1997,281:233~244
  • 5[14]Ducic I,Ko CM,Shuba Y,et al. Comparative effects of loratadine and terfenadine on cardiac K + channels [J]. J Cardiovasc Pharmacol,1997,30:42~54
  • 6[15]Suessbrich H,Waldegger S, Lang F, et al. Blockade of HERC channels expressed in xenopus oocytes by the histamine recepter antagonists terfenadine and astemixole[J]. FEBS, 1996,385: 77~80
  • 7[16]Paserchia LA, Hewett J, Woosley RL, et al. Effect of ketoconazlole on QTc[J]. Clin Pharmacol Ther, 1994,55: 146
  • 8[17]Biton B, Maitre S, Godet D, et al. Effect of the noval nonsedating histamine H1 recepter antagonist mizolastine on cardiac potassium and sodium currents[J]. Allergy, 1998,53: 419
  • 9[18]Leeson GA, Chan KY, Knapp WC, et al. Metabolic disposition of terfenadine in laboratory animals [J]. Arzeimittelforschung, 1982, 32:1173~1178
  • 10[19]Michiels M, Van Peer A, Woestenborghs R, et al. Pharmcokineticsand tissue distribution of astemizole in the dog[J ]. Drug Dev Res,1986,8:53~62

共引文献66

同被引文献15

引证文献6

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部