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内毒素诱导的TLR4-MD2信号传导通路 被引量:12

TLR4-MD2 signaling pathway induced by endotoxin
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摘要 最近研究显示Toll样受体 4 (TLR4 )及其附属蛋白MD2介导内毒素 (LPS)信号 :LPS首先与LPS结合蛋白(LBP)结合 ,再传递给CD14分子 ,形成LPS/LBP/CD14复合物。该复合物与TLR4 MD2相互作用 ,激活胞内的几种信号通路 ,包括NF κB通路和 3种丝裂原活化蛋白激酶通路〔胞外信号调节激酶 (ERK)、c jun氨基末端激酶 (JNK)和p38〕 ,最后导致NF κB和AP 1(c fos/c jun)活化 ,诱导炎性细胞因子表达。 Recent evidence suggests Toll like receptor 4 (TLR4) and its accessory protein MD2 mediate endotoxin/lipopolysaccharide (LPS) signaling. LPS binds to LPS binding protein (LBP) in plasma and is delivered to CD14. Next, LPS is transferred to TLR4 MD2 complex. LPS activates several intracellular signaling pathways that include the NF κB pathway and three mitogen activated peotein kinase (MAPK) pathway: extracellular signal regulated kinase (ERK), c Jun N terminal kinase (JNK) and p38. These signaling pathways in turn activate NF κB and AP 1 (c fos/c jun), which coordinate the induction of many genes encoding inflammatory mediators. Targeting the signaling molecule in the pathway will develop new remedies for treatment of inflammatory disorder.
出处 《中国药理学通报》 CAS CSCD 北大核心 2002年第2期121-125,共5页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助重点项目 No 3 973 0 2 10
关键词 内毒素 诱导 TLR4-MD2 信号传导通路 脂多糖 信号传递 炎症 lipopolysaccharide signal transduction inflammation
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  • 1Sato S,Nomura F,Kawai T et al.Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways[].J Immunol.2000
  • 2Shimazu R,Akashi S,Ogata H et al.MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4[].The Journal of Experimental Medicine.1999
  • 3Poltorak A,He X,Smirnova I et al.Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in TLR4 gene[].Science.1998
  • 4Dziarski R,Wang Q,Miyake K et al.MD-2 enables Toll-Like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to gram-positive and gram-negative bacteria and their cell wall components[].J Immunol.2001
  • 5Yang H,Young DW,Gusovsky F et al.Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4.MD-2 is required for activation of mitogen-activated protein kinases and Elk1[].Journal of Biological Chemistry.2000
  • 6Akashi S,Shimazu R,Ogata H et al.cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages[].J Immunol.2000
  • 7Kikuchi T,Matsuguchi T,Tsuboi N et al.Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via toll-like receptors[].J Immunol.2001
  • 8Irie T,Muta T,Takeshige K.TAK1 mediates an activation signal from toll-like receptor(s) to nuclear-kappaB in lipopolysaccharidestimulated macrophages[].FEBS Letters.2000
  • 9Seki E,Tsutsui H,Nakano H.Lipopolysaccharide-induced IL-18 secretion from murine kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta[].J Immunol.2001
  • 10Arbour NC,Lorenz E,Schutte BC et al.TLR4 mutations are associated with endotoxin hyporesponsiveness in humans[].Nature Genetics.2000

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