HBV非e抗原标志物阳性产妇HBV DNA母乳传播的PCR定量研究

The study on the maternal-milk transmission of HBV in non-HbeAg-positive mothers by fluorogenic quantitative PCR.

目的 :探讨乙肝病毒 (HBV)非e抗原标志物阳性产妇的血清与初乳中HBVDNA含量的关系。方法 :用荧光定量PCR检测 2 6例HBV非e抗原标志物阳性产妇的血清及初乳中HBVDNA含量。结果 :该类产妇初乳中HBVDNA含量明显高于血清中含量 (拷贝值P <0 .0 5 ,荧光值P <0 .0 1)。结论 :在HBV非e抗原标志物阳性产妇HBV不仅可以通过母乳传播 。

Objective:To elucidate the relationship of HBV DNA loads between the serum and the maternal-milk of non-HbeAg-positive mothers.Methods:The HBV DNA loads of the serum and maternal milk of 26 non-HbeAg-positive mothers were determined respectively by fluorogenic quantitative PCR.Results:In these mothers,the maternal-milk HBV DNA level is higher than the serum HBV DNA level obviously.Conclusion:In these non-HbeAg-positive mothers,the maternal-milk transmission is one of the most important transmission ways of HBV.