摘要
目的：研究结核分枝杆菌特异性蛋白（ TB-SA）抗体用于结核病检测的价值。方法可疑结核病患者353例和健康志愿者74例同时进行结核分枝杆菌TB-SA抗体检测和结核菌素纯蛋白衍生物（ PPD）试验，并对可疑结核病患者进行痰涂片显微镜检查和分离培养鉴定。结果结核分枝杆菌TB-SA抗体检测菌阳肺结核的敏感度为87.92%（80/91）；诊断菌阴肺结核的敏感度为78.23%（194/248）；诊断结核病的总体敏感度为81.42%（276/339），特异度为86.36%（76/88）。结论结核分枝杆菌TB-SA抗体检测结核病有较好的敏感度和特异度，有利于结核病的辅助诊断和鉴别诊断。
Objective To investigate the value of tuberculosis specific antigen（ TB-SA）antibody on detecting tuberculosis. Methods The TB-SA antibody levels in the serum of 353 suspect tuberculosis and 74 healthy volunteers were detected by enzyme-linked immunosorbent assay. Tuberculosis was con-formed by clinic,bacteriology,X-ray examination. Results The sensitivity of TB-SA antibody in diag-nosis of bacteriolocally positive and negative pulmonary tuberculosis was 87. 92%（ 80/91 ）and 78. 23%（194/248 ）,respectively;the combined sensitivity was 81. 42%（ 276/339 ）,and the specificity was 86. 36%（76/88）. Conclusions TB-SA antibody has high sensitivity and specificity and is a good tool for detecting tuberculosis.
出处
《中国实用医刊》
2014年第17期1-3,共3页
Chinese Journal of Practical Medicine
基金
河南省医学科技攻关计划项目（201203126）
