中医标本同治法配合克罗米芬治疗多囊卵巢综合征性不孕临床疗效观察

Observation on the clinical efficacy of simultaneous treatment of principal and subordinate symptoms according to theory of traditional Chinese medicine combined with clomiphene in treatment of infertility caused by polycystic ovary syndrome

目的：探究中医标本同治法配合克罗米芬治疗多囊卵巢综合征性不孕的临床疗效。方法：选取2010年3月-2013年6月在该院进行医治的多囊卵巢综合征性不孕患者96例,将其平均分为两组,每组48例。实验组患者使用中医标本同治法联合克罗米芬进行治疗,对照组患者仅使用克罗米芬进行治疗,均以2个月为1个治疗周期,把两组患者的内分泌激素、排卵时期、妊娠情况以及临床主要表现作为检测指定的标准。结果：实验组患者机体内分泌激素水平明显优于对照组,差异有统计学意义（P〈0.05）;实验组患者的排卵情况和妊娠率明显高于对照组,差异有统计学意义（P〈0.05）;实验组患者的总有效率（93.75%）明显高于对照组（62.50%）,差异有统计学意义（P〈0.05）。结论：将中医标本同治法联合克罗米芬用于治疗多囊卵巢综合征性不孕患者比仅使用克罗米芬治疗的效果好,患者的症状得到明显改善,不良反应较少,在临床上可以广泛运用。

Objective： To explore the clinical efficacy of simultaneous treatment of principal and subordinate symptoms according to theory of traditional Chinese medicine combined with clomiphene in treatment of infertility caused by polycystic ovary syndrome （PCOS） . Methods： A total of 96 infertile patients caused by PCOS treated in the hospital from March 2010 to June 2013 were selected and divided into two groups, 48 patients in each group. The patients in experimental group were treated with simultaneous treatment of principal and subordinate symptoms according to theory of traditional Chinese medicine combined with clomiphene, while the patients in control group were treated with clomiphene, two months were designed as one course of treatment; the levels of endocrine hormones, ovulation periods, pregnancy rates and main clinical manifestations in the two groups were detected. Results： The levels of endocrine hormones in experimental group were statistically significantly better than those in control group （ P 〈 0. 05） ; the ovulation rate and pregnancy rate in experimental group were statistically significantly higher than those in control group （ P 〈 0. 05 ） ; the total effective rate in experimental group was 93.75% , which was statistically significantly higher than that in control group （62. 50% ） （P 〈 0. 05） . Conclusion： Compared with simple application of clomiphene, the curative effect of simultaneous treatment of principal and subordinate symptoms according to theory of traditional Chinese medicine combined with clomiphene in treatment of infertile patients caused by PCOS is better, the symptoms are improved obviously, the adverse reactions are few, which can be used in clinic widely.