秋泻灵合剂与潘生丁联合治疗小儿秋季腹泻的临床疗效观察

Observation on Clinical Effect of Qiuxieling Mixture and Dipyridamole Therapy on Children Diarrhea

目的：探讨秋泻灵合剂与潘生丁联合治疗小儿秋季腹泻的临床疗效及安全性。方法：选取116例秋季腹泻患儿,随机分为对照组和治疗组,两组患儿均给与止泻、退热、调整电解质平衡等常规治疗,同时对照组给予潘生丁[5 mg/（kg·day）,分2～3次口服]进行治疗,治疗组在此基础上加用秋泻灵合剂（5～10 mL/次,4次/日）,两组均连续治疗3 d,观察两组患儿临床症状及体征改善情况及不良反应。结果：经治疗后,对照组总有效率为94.8%,治疗组总有效率为79.3%,治疗组总有效率明显高于对照组,具有显著性差异（P〈0.05）;治疗组各生理指标复常时间较对照组明显缩短,具有显著性差异（P〈0.05）;两组均未出现严重的不良反应。结论：秋泻灵合剂与潘生丁联合用于治疗小儿秋季腹泻,可明显改善患儿的生理指标,具有临床疗效较好,不良反应少等特点,具有一定的临床借鉴意义。

Objective： To explore the clinical efficacy and safety of the Qiuxieling mixture and Dipyridamole therapy on the children diarrhea. Method： 116 cases of autumn diarrhea were randomly divided into control and treatment groups. Two groups patients were given conventional treatments for diarrhea,fever,adjusting the electrolyte balance while the control group received dipyridamole [5 mg /（kg·day）,2 ～ 3 times a day orally]for the treatment group based on the use of Qiuxieling mixture（5 ～ 10 mL,4 times /day）. Three days of continuous treatment in both groups were observed in children with clinical symptoms and signs of improvement and adverse reactions. Results： After treatment,the treatment group＇s total effective rate was 94. 8% and the control group＇s total effective rate was 79. 3% and the treatment group was significantly higher with a significant difference（P〈0. 05）. The treatment group＇s physiological normalization time was significantly shorter than that of the control group with a significant difference（P〈0. 05）. Two groups had no serious adverse reactions. Conclusion：Qiuxieling mixture combined with dipyridamole for the treatment of infantile diarrhea can significantly improve children＇s physiological indicators with better clinical efficacy and few adverse reactions and other characteristics and has certain clinical reference.