关于药物洗脱支架再狭窄研究的进展

Research progress for in-stent restenosis of drug-eluting stent

支架内再狭窄是介入治疗技术中面临的重要医学难题,药物洗脱支架明显降低支架内再狭窄率,然而在抑制血管平滑肌细胞过度增殖的同时,也抑制了支架处内皮功能和生长,其内皮化延迟可导致晚期再狭窄及延迟血栓的形成。本文就药物洗脱支架再狭窄现状、影响因素、发生机制和各种治疗方法的研究进展做一综述。

In-stent restenosis is an important medical problem in interventional therapy .Drug-eluting stent （DES） can significantly reduce in-stent restenosis rate .However ,it also inhibits function and growth of endothelium in stent site while inhibiting over-proliferation of vascular smooth muscle cells .Delayed endothelialization can lead to late restenosis and delayed thrombosis .The present article made an overview on research progress of DES restenosis current condition ,influencing factors ,mechanisms and various therapeutic methods .