组织块移植法建立人肺癌裸鼠移植瘤模型

The Establishment of Patient-derived Lung Cancer Xenograft Models by Cancer Tissue Transplant Directly

肺癌对人类的健康构成了严重的威胁,人肺癌裸鼠移植瘤模型的建立对于肺癌的研究是一项重要的工具.建立肺癌移植瘤模型的方法主要有细胞培养移植法、组织块移植法和匀浆液移植法.组织块移植法建立的模型能最大限度地模拟人体内环境,是一种理想的模型.就组织块移植法建模的操作方法及当前研究进展作一综述.

Lung cancer is a threat to human health. It will be a significant tool for studying on lung cancer to establish a patient-derived lung cancer xenograft model. There are three approaches to establishing a lung cancer xenograft model, lung cancer cell culturing, lung cancer tissues transplant and cancer tissue plasma transplant. Xenograft model has been considered an idea research model for human lung cancer because it reflects human internal environment of lung cancer itself. In this paper, we focus on recent advances in establishing xenograft model for human lung cancer studies.