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核素^(89)SrCl_2治疗骨转移瘤患者的临床观察 被引量:4

Clinical Observation of ^(89)SrCl_2 Therapy in Patients with Bone Metastases
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摘要 目的探讨核素89SrCl2对骨转移瘤患者的治疗效果。方法 75例肿瘤患者经全身骨扫描显像证实存在多发性骨转移瘤,使用核素89SrCl2治疗后,通过统计分析比较治疗前后骨痛的缓解程度、外周血象的改变及骨转移灶变化情况。结果核素89SrCl2治疗骨转移瘤疗效明确,75例患者中60例疼痛出现不同程度的缓解,缓解率达80%(P<0.01),其中19例患者疼痛完全消失;而治疗前后外周血象无明显改变;患者骨转移灶缓解率达89%(P<0.01)。结论核素89SrCl2对骨转移瘤患者的止痛效果好,毒副反应小,且骨转移灶缓解率高,是一种有效的治疗手段。 Objective To investigate the therapeutic effects of strontium-89 therapy in patients with bone metastases. Methods Seventy-five cancer patients with multiple bone metastases confirmed with whole body bone scan imaging were treated with strontium-89. The catabolic effects of bone pain, the changes of peripheral hemogram and bone metastases lesions were analyzed before and after strontium-89 therapy. Results Among seventy-five cases of patients, sixty cases appeared different degree of pain relief, and the remission rate was 80% (P 〈 0. 01 ); Nineteen patients pain disappeared completely. There was no significant change for peripheral hemogram during treatment period and the bone metastases remission rate in all cancer patients was 89% (P 〈0.01 ). Conclusion Strontium-89 therapy is an effective therapeutic method for patients with bone metastases with favorable effects on relieving pain, low reaction of toxicity and high remission rate.
作者 胡德胜 石磊
出处 《标记免疫分析与临床》 CAS 2014年第5期540-542,共3页 Labeled Immunoassays and Clinical Medicine
关键词 89SrCl2 骨转移瘤 肿瘤 核素治疗 Nuclide strontium-89 Bone metastasis Cancer Radionuclide therapy
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