雌三醇联合阴道电刺激与生物反馈治疗更年期压力性尿失禁疗效观察

Effect of estriol cream combined with vaginal stimulation and biofeedback treatment in treating menopausal stress urinary incontinence

目的:研究雌三醇联合阴道电刺激与生物反馈治疗更年期压力性尿失禁的疗效。方法:将2011年3月至2013年5月期间我院收治的更年期压力性尿失禁患者纳入研究,随机分为给予欧维婷雌三醇乳膏联合阴道电刺激与生物反馈治疗的观察组和仅给予阴道电刺激与生物反馈治疗的对照组,观察盆底肌肉张力、尿道功能指标。结果:治疗后2个月及6个月后,观察组患者的阴道静息压(35.67±8.20、38.25±9.24)cm H2O、阴道收缩压(39.44±11.32、42.32±9.12)cm H2O、阴道收缩持续时间(5.72±0.54、6.56±1.63)s、功能性尿道长度(35.31±6.32、37.67±8.42)mm、最大尿道关闭压(39.58±8.42、38.22±7.14)cm H2O明显高于对照组(P<0.05);尿失禁量(0.66±0.34、0.18±0.12)g显著低于对照组(P<0.01)。结论:雌三醇乳膏联合阴道电刺激与生物反馈治疗有助于增强盆底肌肉张力、优化尿道功能,在更年期压力性尿失禁的治疗中具有积极价值。

Objectives： To study the effect of estriol cream combined with vaginal stimulation and biofeedback treatment in treating menopausal stress urinary incontinence. Methods： The menopausal stress urinary incontinence patients in our hospital from 2011 March to May 2013 were enrolled and randomly divided into observation group given estriol cream combined with vaginal stimulation and biofeedback treatment and control group only given vaginal stimulation and biofeedback treatment. The pelvic floor muscle tension,urethra function index of the two groups were observed. Results： After 2 and 6 months treatment,the vaginal resting pressure（ 35. 67 ± 8. 20,38. 25 ±9. 24） cm H2 O,vaginal systolic pressure（ 39. 44 ± 11. 32,42. 32 ± 9. 12） cm H2 O,vaginal contraction duration（ 5. 72 ± 0. 54,6. 56 ± 1. 63） s,functional urethral length（ 35. 31 ± 6. 32,37. 67 ± 8. 42） mm,maximum urethral closure pressure（ 39. 58 ± 8. 42,38. 22 ± 7. 14） cm H2 O of the observation group were significantly higher than those of control group（ P〈0. 05）; Urinary incontinence（ 0. 66 ± 0. 34,0. 18 ± 0. 12） g were significantly lower than that of control group（ P〈0. 01）. Conclusion： Estriol cream combined with vaginal stimulation and biofeedback treatment have positive clinical value in treating menopausal stress urinary incontinence,since it can enhance pelvic floor muscle tension and improve urethra function.