HSF1与XAF1基因在子宫内膜癌组织中的表达及其相关性分析

The expressions of HSFl and XAF1 in endometrial carcinoma and their correlation analysis

目的检测HSF1与XAF1基因在子宫内膜组织中的表达,分析其与临床病理学特征的关系。方法采用免疫组织化学S-P法检测64例子宫内膜癌组织(EC组)、33例正常子宫内膜组织(NE组)中两者的表达情况,并观察其相关性。结果子宫内膜癌组织中HSF1阳性表达率为76.6%,显著高于正常子宫内膜组织36.4%(P<0.05);子宫内膜癌及正常子宫内膜组织XAF1阳性率分别为31.2%和72.7%,差别具有统计学意义(P<0.05);在EC组中HSF1的阳性表达率在不同的组织学分级、肌层浸润及淋巴结转移间差异有统计学意义(P<0.05);在EC组中XAF1的阳性表达率在不同的组织学分级、肌层浸润、手术病理分期及淋巴结转移间差异有统计学意义(P<0.05);子宫内膜癌组织中HSF1与XAF1表达水平呈负相关(P<0.05)。结论在子宫内膜癌组织中HSF1的高表达可能通过抑制XAF1的表达致使细胞过度生长,抑制肿瘤细胞发生凋亡,导致肿瘤进一步发展。

Objective To test the expressions of heat shock transcription factor 1 （HSF1 ）and XIAP-associated factor 1 （XAF1 ）in different endometrial tissues,and analyze the association between their expressions and the clinicopathological features of this malignancy.Methods The expressions of HSF1 and XAF1 in 64 cases of endometria1 carcinoma （EC group）and 33 cases of normal endometrial tissues （NE group）were detected with immunohistochemistry S-P method.The correlation was observed.Results The positive expression rate of HSF1 was much higher in EC group than in NE group （76.6% vs .36.4%,P 〈0.05）.The positive rate of XAF1 was 31.2% in EC group and 72.7% in NE group （P 〈0.05）.The positive expressions of HSF1 and different subgroups of histological grade,myometrial invasion and lymph node metastasis were significantly different （P 〈0.05）in EC group.The positive expressions of XAF1 and different subgroups of histological grade,myometrial invasion,clinical stage and lymph node metastasis were significantly different （P 〈 0.05 ）in EC group.There was a negative correlation between HSF1 and XAF1 in EC group （P 〈0.05）.Conclusion In EC group,the high expression of HSF1 may inhibit the growth of XAF1 expression,cause excessive growth of cancer cells,reduce the apoptosis of cancer cells,and finally lead to the further development of tumors.