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Glypican-3在胚胎及肿瘤中的生物学研究进展 被引量：1

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摘要 磷脂酰肌醇聚糖-3蛋白（Glypican-3,GPC3,也称为DGSX,GTR2-2,MXR7,OCI-5,SDYS,SGB,SGBS和SGBS1）是硫酸乙酰肝素糖蛋白（heparan sulfate proteoglycan,HSPG）家族的成员之一,可通过共受体结合相关配基,如生长因子、细胞黏附分子、酶和酶抑制剂、基质成分等,参与调节细胞增殖、分化、黏附和迁移等过程,同时参与调节大部分中胚层组织和器官形成过程。近年来大量研究表明,
作者 薛冉 孟庆华
机构地区 首都医科大学附属北京佑安医院肝病重症医学科
出处 《肝脏》 2015年第1期75-78,共4页 Chinese Hepatology
基金 首都卫生发展科研专项项目(首发2011-2018-09)
关键词 胚胎干细胞 磷脂酰肌醇聚糖 硫酸乙酰肝素 GLYPICAN-3 卵黄囊瘤 PROTEOGLYCAN 细胞黏附分子 黑素瘤 heparan 结直肠癌
分类号 R346 [医药卫生—基础医学]
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  • 1Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong 226001,China (Yao M,Yao DF,Qiu LW,Wu W,Sai WL,Yang JL and Zhang HJ),Department of Oncology,Yancheng First People’s Hospital,Yancheng 224001,China (Bian YZ),Department of Oncology,Second Affiliated Hospital,Nanjing Medical University,Nanjing 210011,China (Zhang CG).Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma[J].Hepatobiliary & Pancreatic Diseases International,2011,10(3):289-294. 被引量：53
  • 2Min Yao,Deng-Fu Yao,Yin-Zhu Bian,Wei Wu,Xiao-Di Yan,Dan-Dan Yu,Li-Wei Qiu,Jun-Ling Yang,Hai-Jian Zhang,Wen-Li Sai,Jie Chen.Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma[J].Hepatobiliary & Pancreatic Diseases International,2013,12(2):171-179. 被引量：19
  • 3Martha L. Peterson,Chunhong Ma,Brett T. Spear.Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer[J]. Seminars in Cancer Biology . 2011 (1)
  • 4Dongye Yang,Junwen Yang,Fanggen Lu,Caihong Li,Jingbo Yang,Jieling Liang.A new membrane re-anchored protein originating from GPC3 against hepatomacells HepG2[J]. Molecular Medicine Reports . 2011 (6)
  • 5C. Buchanan,I. Stigliano,H. M. Garay-Malpartida,L. Rodrigues Gomes,L. Puricelli,M. C. Sogayar,E. Bal de Kier Joffé,M. G. Peters.Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways[J]. Breast Cancer Research and Treatment . 2010 (3)
  • 6Bowen Liu,Shirish Paranjpe,William C. Bowen,Aaron W. Bell,Jian-Hua Luo,Yan-Ping Yu,Wendy M. Mars,George K. Michalopoulos.Investigation of the Role of Glypican 3 in Liver Regeneration and Hepatocyte Proliferation[J]. The American Journal of Pathology . 2009 (2)
  • 7Weiping Zhang,Jing Mi,Nan Li,Lili Sui,Tao Wan,Jia Zhang,Taoyong Chen,Xuetao Cao.Identification and Characterization of DPZF, a Novel Human BTB/POZ Zinc Finger Protein Sharing Homology to BCL-6[J]. Biochemical and Biophysical Research Communications . 2001 (4)
  • 8David K. Jin,Miriam H. Feuerman.Genetic mapping of Afr2 (Rif) : regulator of gene expression in liver regeneration[J]. Mammalian Genome . 1998 (3)

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肝脏
2015年 第1期

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