磷酸化小窝蛋白-1在食管鳞癌中的表达及意义

Significance of PY14caveolin-1 expression in esophageal squamous cell carcinoma

目的:检测磷酸化小窝蛋白-1(PY14caveolin-1,PY14cav-1)在不同食管组织中的表达,探讨PY14cav-1与食管癌发生、发展的关系。方法:收集60例食管鳞状细胞癌患者手术标本,采用免疫组织化学方法分析和检测PY14cav-1在食管癌组织、癌旁组织及正常食管组织中的表达情况,分析PY14cav-1表达水平与食管癌发生、发展的关系。结果:PY14cav-1在食管鳞癌组织中的表达水平明显高于癌旁组织与食管正常组织中的表达水平,差异具有统计学意义(P<0.05)。PY14cav-1与食管癌的临床分期呈正相关性,随着肿瘤临床分期的升高表达增强,差异具有统计学意义(P<0.05)。淋巴结转移组中PY14cav-1的表达明显高于无淋巴结转移组,差异具有统计学意义(P<0.05)。PY14cav-1的表达与肿瘤的分化程度呈负相关性(P=0.034)。结论:PY14cav-1的表达与食管癌分化程度、临床分期和淋巴结转移有关,可能参与了食管癌的侵袭和转移,在食管癌的发生和发展过程中起着重要的作用,很可能成为潜在的治疗靶点及判断食管癌预后有价值的肿瘤标记物。

Objective：To detect the expression of PY14caveolin - 1 in different esophageal tissues,and study the relationship between the expression of PY14caveolin - 1 and the occurrence and development of esophageal squamous cell carcinoma. Methods：We collected the fresh surgical specimens in 60 patients with esophageal squamous cell car-cinoma. Immunohistochemistry was used to detect the expression of PY14caveolin - 1 in esophageal squamous cell carcinoma,adjacent esophageal tissues and normal esophageal tissues. Results：The expression of PY14caveolin - 1 in esophageal squamous cell carcinoma was much higher than in adjacent tissues and normal esophageal tissues（P 〈0. 05）. The expression of PY14caveolin - 1 was positive correlated with the clinical stage of esophageal squamous cell carcinoma. The expression intensity gradually increased with the advance of clinical stages,the differences being sta-tistically significant（P 〈 0. 05）. The positive rate of PY14caveolin - 1 in with group of lymph node metastasis was significantly higher than that without lymph node metastasis,the differences being statistically significant（P 〈 0. 05）. The expression of PY14caveolin - 1 was negatively related to the differentiated degree of esophageal squamous cell carcinoma,the differences being statistically significant（P = 0. 034）. Conclusion：The expression of PY14caveolin -1 is correlated with the differentiation,clinical stage and lymph node metastasis of esophageal squamous cell carcino-ma,it may be involved in the migration and invasion of esophageal cancer. PY14caveolin - 1 will be a potential thera-peutic target and a valuable prognostic indicator of esophageal cancer progression.