淋巴系统增殖性疾病患者EB病毒感染的检测结果分析

Analysis of the Detection for the LPD Patients with EB Infection

目的:分析淋巴系统增殖性疾病(lymphoproliferative disease,LPD)患者EB病毒(Epstein-Barr virus,EBV)感染的检测结果。方法:回顾性分析70例LPD患者与70例健康志愿者血清EBV特异性抗体、血清细胞因子以及单个核细胞中EBV DNA拷贝数检测结果。结果:两组入选者血清VCA-Ig G和VCA-Ig M阳性率比较,无明显差异(P>0.05);PLD组患者血清EA-Ig G阳性率显著高于正常对照者(P<0.05);两组入选者血清IL-18、IFN-γ水平无明显差异(P>0.05);PLD患者EBV DNA拷贝数显著高于正常对照者(P<0.05)。结论:LPD患者存在EBV的激活感染,是导致LPD患者淋巴系统功能异常的主要原因,EBV的激活感染可能参与LPD的发病过程。

Objective： To analyze the detection results for the patients with lymphoproliferative disease （LPD） accompanied with the infection of EB. Methods： The EBV specific antibody, serum cytokine, EBV DNA copy number in peripheral blood mononuclear cells （ PBMNC ） of 70 LPD patients and 70 healthy volunteers were analyzed and compared. Results： The positive rates of VCA-IgG and VCA-IgM were not significantly different in two groups （P 〉 0. 05） ; The positive rate of EA-IgG in the PLD patient group was higher than that in the control group（P 〈0.05） ; the levels of IL-18 and IFN-γ were not significantly different between the 2 group （P 〉0.05） ; the EBV DNA copy number in PBMNC of the PLD patient group was higher than that in the control group （ P 〈 0.05 ）. Conclusion： The patients with LPD show the active infection of EBV, that is the main reason for the abnormal function of lymphatic system in the patients with LPD. The active infection of EBV maybe involve in PLD pathogenesis.