外周血结核感染T淋巴细胞斑点试验对活动性结核的诊断价值

目的：探讨结核感染T细胞斑点试验（T—SPOT．TB）在诊断活动性结核中的价值。方法：通过对2011年3月-2014年12月医院56疑似结核菌感染例住院病例的T—SPOT．TB的检测结果：进行回顾性分析，评估T—SPOT．TB检测在诊断活动性结核病的价值。结果：56例患者中结核组即诊断活动性结核共31例，斑点数为222．1±179．9，其中阳性28例，其中非结核组25例，斑点数为74．3±141．1，其中阳性结果t2例，阴性结果13倒。两组检测结果存在显著差异，结果显示结核感染T细胞斑．量试验对活动性结核组的敏感性为90．3％，特异性为52％，其阳性预测值为70％，阴性预测值为81％。结论：T—SPOTTB用于鉴定活动性菌感染，其敏感性高，阳性预测值及阴性预测值较高，特异性较差，对于快速诊断结核，提高结核病的诊断水平有所帮助，有进一步推广价值。

Objective ： To investigate the value of tuberculosis infection T cell spot test （ T - SPOT. TB） in the diagnosis of active tuberculosis. Methods ： from March 2011 to December 2014 ,56 eases of hospitalized eases of suspected TB infection T - SPO T. TB test results were retrospectively analyzed to assess the T - SP OT. T B in the diagnosis of active TB value. Results： 56 patients with active TB diagnostic group that is a total of 31 cases of tuberculosis, the number of spots was 222. 1 ± 179. 9, including the positive results of 28 eases ; 25 cases of non - tuberculosis group, the number of spots was 74. 3 ± 141.1, including 12 eases of positive results, negative results 13 cases. Two test results were signifi- cantly different,its showed that Tuberculosis infection T cell spot test for active TB group sensitivity 90. 3%, specificity 52%, positive predictive value 70%, negative predictive value was 81%. Conclusion： T - SPOT. TB for the identification of active TB infection, its high sensitivity, positive predictive value and negative predictive value high, poor specificity for rapid diagnosis of tuberculosis, improve the diagnosis of tuberculosis helpful, there are further promotional value.