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Minimally manipulated autologous adherent bone marrow cells (ABMCs):a promising cell therapy of spinal cord injury 被引量：3

Minimally manipulated autologous adherent bone marrow cells (ABMCs): a promising cell therapy of spinal cord injury
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摘要 Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorrhage and vasospasm.Post injury,secondary damage is caused by ischemia, Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorrhage and vasospasm.Post injury,secondary damage is caused by ischemia,
作者 Kamana Misra Hatem E.Sabaawy
机构地区 Celvive Inc. Departments of Neuroscience and Cell Biology Cellular and Molecular Pharmacology Rutgers Cancer Institute of New Jersey
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第7期1058-1060,共3页 中国神经再生研究（英文版）
关键词 BONE CELL Minimally manipulated autologous adherent bone marrow cells a promising cell therapy of spinal cord injury ABMCs MSCS
分类号 R651.2 [医药卫生—外科学]
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参考文献11

  • 1E1-Kheir WA, Gabr H, Awad MR, Ghannam O, Barakat Y, Farghali HA, E1 Maadawi ZM, Ewes I, Sabaawy HE (2014) Autologous bone mar- row-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients. Cell Transplant 23:729-745.
  • 2Gabr H, E1-Kheir WA, Farghali HA, Ismail ZM, Zickri MB, Maadawi ZM, Kishk NA, Sabaawy HE (2014) Intrathecal transplantation of autologous adherent bone marrow cells induces functional neurolog- ical recovery in a canine model of spinal cord injury. Cell Transplant doi:10.3727/096368914X683025.
  • 3Liang X, Ding Y, Zhang Y, Tse HF, Lian Q (2014) Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspec- tives. Cell Transplant 23:1045-1059.
  • 4Marino RJ, Graves DE (2004) Metric properties of the ASIA motor score: subscales improve correlation with functional activities. Arch Phvs Med Rehabil 85:1804-1810.
  • 5McDonald IW, Sadowsky C (2002) Spinal-cord injury. Lancet 359:417- 425.
  • 6Misra K, Luo H, Li S, Matise M, Xiang M (2014) Asymmetric activation of D114-Notch signaling by Foxn4 and proneural factors activates BMP/TGFbeta signaling to specify V2b interneurons in the spinal cord. Development 141:187-198.
  • 7Patel N, Klassert TE, Greco SI, Patel SA, Munoz IL, Reddy BY, Bryan M, Campbell N, Kokorina N, Sabaawy HE, Rameshwar P (2012) Devel- opmental regulation of TAC1 in peptidergic-induced human mes- enchymal stem cells: implication for spinal cord injury in zebrafish. Stem Cells Dev 21:308-320.
  • 8Prockop DJ (2009) Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. Mol Ther 17:939-946.
  • 9Steeves JD, Lammertse D, Curt A, Fawcett JW, Tuszynski MH, Ditunno JF, Ellaway PH, Fehlings MG, Guest JD, Fleitman N, Bartlett PF, Blight AR, Dietz V, Dobkin BH, Grossman R, Short D, Nakamura M, Cole- man WP, Gaviria M, Privat A, et al. (2007) Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord 45:206-221.
  • 10Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined fac- tors. Cell 126:663-676.

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Neural Regeneration Research
2015年 第7期

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