慢性肺源性心脏病失代偿期患者NT-proBNP和肌钙蛋白Ⅰ的表达及意义

Expression and significance of NT-pro BNP and troponin I in patients of chronic pulmonary heart disease decompensated stage

目的分析慢性肺源性心脏病失代偿期患者N末端B型利钠肽原(NT-pro BNP)和肌钙蛋白I的表达及其临床意义。方法 97例慢性肺源性心脏病患者,根据病情分为代偿期组61例与失代偿期组36例,并选取28例健康体检者作为对照组,评估各组研究对象的肺功能指标,检测各组研究对象血浆中NT-pro BNP和肌钙蛋白I的表达水平。结果失代偿期组患者一秒钟用力呼吸容积(FEV1)、一秒钟用力呼气容积占用肺活量百分比(FEV1/FVC)、最大呼气流速峰值(PEF)及用力肺活量(FVC)与代偿期组及对照组相比差异均具有统计学意义(P<0.05);失代偿期组患者NT-pro BNP及肌钙蛋白I显著高于代偿期组和对照组,差异均具有统计学意义(F=326.2、299.6,P<0.05)。结论 NT-pro BNP及肌钙蛋白I可能参与慢性肺源性心脏病的发生发展过程,对于慢性肺源性心脏病的早期诊断提供了一定的实验依据。

Objective To analyze expression and clinical significance of N-terminal pro brain natriuretic peptide（NT-pro BNP） and troponin I in patients of chronic pulmonary heart disease decompensated stage. Methods A total of 97 patients with chronic pulmonary heart disease were divided by disease condition into compensated stage group with 61 cases and decompensated stage group with 36 cases. Another 28 healthy people were chosen as control group. Pulmonary function indexes of these groups were evaluated, and expression levels of NT-pro BNP and troponin I were detected. Results The decompensated stage group had statistically significant differences with the compensated stage group and the control group in forced expiratory volume in 1 second（FEV1）, proportion of forced expiratory volume in 1 second in forced vital capacity（FEV1/FVC）, peak expiratory flow（PEF）, and forced vital capacity（FVC）（P〈0.05）. The decompensated stage group also had obviously higher NT-pro BNP and troponin I than the compensated stage group and the control group, and their difference had statistical significance（F=326.2, 299.6, P〈0.05）. Conclusion NT-pro BNP and troponin I may be involved in occurrence and progression of chronic pulmonary heart disease, and they provides certain experimental evidence for early diagnosis of chronic pulmonary heart disease.