儿童眼外伤性角膜损伤或穿孔行多层羊膜覆盖治疗的研究

Study of multilayer amniotic membrane covering therapy for the treatment of traumatic corneal injury or perforation in children

目的：研究儿童眼外伤性角膜损伤或穿孔行多层羊膜覆盖治疗的效果。方法：随机选取2012-05/2015-05我院收治的儿童眼外伤性角膜损伤或穿孔患儿60例72眼,依据治疗方法将这些患儿分为两组,研究组30例36眼和对照组30例36眼。给予对照组患儿单层羊膜覆盖治疗,给予研究组患儿多层羊膜覆盖治疗。结果：研究组患儿的羊膜持续时间显著长于对照组（P〈0.05）,角膜水肿消退时间均显著短于对照组（P〈0.05）,新生血管生成〈3个象限比例28%（10/36）显著高于对照组17%（6/36）（P〈0.05）,无生成比例11%（4/36）显著低于对照组28%（10/36）（P〈0.05）,视力为0.3~1.0占11%（4/36）显著高于对照组3%（1/36）（P〈0.05）,手动/眼前~0.1占56%（20/36）显著低于对照组72%（26/36）（P〈0.05）。结论：儿童眼外伤性角膜损伤或穿孔行多层羊膜覆盖治疗的效果良好。

AIM：To study the effect of multilayer amniotic membrane covering therapy for the treatment of traumatic corneal injury or perforation in children.METHODS：Sixty cases（72 eyes） were randomly selected from the children with traumatic corneal injury or perforation from May 2012 to May 2015 in our hospital.They were divided into two groups according to the different treatments,the study group（30 patients with 36eyes） and the control group（30 patients with 36 eyes）.The patients in control group were given single layer amniotic membrane covering treatment,while those in study group were given multilayer amniotic membrane covering treatment.RESULTS：The duration of the amniotic membrane of the study group was significantly longer than that of the control group（P〈0.05）.The corneal edema time was significantly shorter（P〈0.05）.The rate of patients who had angiogenesis 3 quadrants was 28%（10/36）,which was significantly higher than that of the control group 17%（6/36）（P 0.05）.The rate of patients without angiogenesis was 11%（4/36）,which was significantly lower than that of the control group 28%（10/36）（P〈0.05）.The rate of patients with the visual acuity 0.3 ~1.0in observation group was 11%（4/36）,which was significantly higher than that of the control group 3%（1/36）（P〈0.05）.The rate of patients with visual acuity hand motion/before eyes ~ 0.1 was 56%（20/36）,which was significantly lower than that of the control group 72%（26/36）（P〈0.05）.CONCLUSION：The multilayer amniotic membrane covering therapy was effective on the treatment of traumatic corneal injury or perforation in children.