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同步放化治疗老年人局部晚期下咽癌的临床观察 被引量:6

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摘要 目的:观察调强放疗联合紫杉醇治疗老年局部晚期下咽癌的近期疗效和毒副反应。方法64例老年局部晚期下咽癌患者,按治疗方法不同分为调强放疗加紫杉醇组(调强+化组)和适形放疗组(适形组),各32例。调强+化组采用6MV-X射线调强放疗,照射剂量66~70 Gy ,1.8~2.0 Gy/次,1次/d,5 d/周。每周给予紫杉醇60 mg静脉滴注(从放疗第2天开始);适形组采用6MV-X射线照射,照射剂量68~70 Gy,1.8~2.0 Gy/次,1次/d,5 d/周。观察两组临床疗效。结果调强+化组CR 27例(84.4%),适形组CR 20例(62.5%),两组比较差异有统计学意义(P〈0.05);调强+化组与适形组毒副反应中胃肠道反应、口腔黏膜反应比较差异无统计学意义(P〉0.05);调强+化组骨髓抑制明显高于适形组(P〈0.05);调强+化组1年生存率明显高于适形组(P〈0.01);调强+化组3年生存率明显高于适形组(P〈0.05)。结论调强放疗联合紫杉醇治疗老年局部晚期下咽癌有很好的近期疗效,毒副反应较轻,能被老年患者耐受,可在临床进一步推广。
作者 王岚 杨长滨
出处 《中国实用医药》 2015年第29期146-147,共2页 China Practical Medicine
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