速效救心丸联合盐酸替罗非班氯化钠注射液治疗急性冠脉综合征患者临床疗效及对血清hs-CRP；Cys-C及BNP的影响

JiuXinWan Joint Tirofiban Hydrochloride Sodium Chloride Injection in the Treatment of Patients with Acute Coronary Clinical Efficacy and its Effects on Hypersensitive CRP, Cys-C and BNP Levels

【目的】探讨速效救心丸联合盐酸替罗非班氯化钠注射液治疗急性冠脉综合征（ACS）患者临床疗效及其对患者血清超敏c反应蛋白（hs-CRP）、胱抑素C（Cys-c）及B型脑钠肽（BNP）的影响。【方法1106例ACS患者根据随机分组法分为对照组（n=54）和观察组（n=52）。对照组单用盐酸替罗非班氯化钠注射液治疗，治疗组在对照组基础上加用速效救心丸。两组疗程均为1个月。对比分析两组心绞痛和心电图疗效，hs-CRP、Cys-C及BNP水平，心绞痛发作次数和持续时间及不良心血管事件。【结果】观察组心绞痛总有效率（87．04％）显著高于对照组（71．15％）（P〈0．05）；观察组心电图总有效率（75．93％）显著高于对照组（59．62％）（P〈0．05）；治疗后，两组患者血清hs-CRP、Cys-C及BNP水平均低于治疗前（P〈0．05）；观察组患者血清hs-CRP、Cys-C及BNP水平均低于对照组（P〈0．05）；观察组心绞痛发作次数治疗后显著少于对照组（P〈0．05），持续时间显著短于对照组（P〈0．05）；治疗组不良心血管事件发生率显著少于对照组（P〈O．05）。【结论】速效救心丸联合盐酸替罗非班氯化钠注射液治疗急性冠脉综合征疗效显著，可明显降低患者血清hs-cRP、Cys-C及BNP水平。

[Objective]To explore Joint JiuXinWan Tirofiban Hydrochloride Sodium Chloride injection in the treatment of patients with Acute Coronary Syndrome （ACS） and its effect on hypersensitive CRP, Cys-C and BNP syndrome. [Methods] The 106 cases of patients with ACS were randomly divided into the control group （ n = 54） and treatment group （ n = 52）. Both the control group and the treatment group were treated with Tirofiban Gydrochloride Sodium Chloride Injection therapy. However, the treatment group was also treated with JiuXinWan. The treatment period lasted a month. Afterwards, a compar- ison of the two groups was made regarding angina and electrocardiogram （ECG） efficacy, hypersensitive C reaction protein （hs-CRP）, Cys-C and BNP levels, as well as the duration of angina attacks and adverse cardiovascular events. [Results]Oc- currences of angina in the treatment group decreased （87.04%） and was significantly lower than that of the control group （71.15 %） （P〈0.05）; the electrocardiogram results of the treatment group （75. 93% ） were significantly better as well （59.62%） （ P〈0.05）. After treatment, levels of serum hypersensitive CRP, Cys-C, and BNP were lower in both groups compared to their pre-treatment levels （ P〈0.05） ; levels were lower in the treatment group compared to the control group （ P〈0.05）. Angina Pectoris episodes after treatment was significantly less frequent in the control group （ P 〈0.05）, and the duration significantly shorter in both groups （P〈0.05 ）. The adverse cardiovascular events were significantly less in both groups （ P〈0.05）. [Conclusion] JiuXinWan Joint Tirofiban Hydrochloride Sodium Chloride Injection Treatment of acute coronary syndrome can significantly reduce serum levels of hs-CRP, Cys-C and BNP 1 and it is proved quite effective.