低分子肝素钠治疗脓毒症患者30例分析

Analysis of low molecular weight heparin sodium for the treatment of 30 cases of patients with sepsis

目的:探讨低分子肝素钠对脓毒症患者血液流变与凝血指标的影响。方法:回顾性研究分析我院ICU脓毒症患者60例,采用随机数字表法将其分为对照组和观察组各30例,对照组采用常规治疗,观察组在对照组基础上采用低分子肝素钠,比较临床疗效、血液流变与凝血指标的差异。结果:治疗前,两组患者APACHEⅡ评分、CRP、WBC、血液流变指标与凝血指标水平比较差异无统计学意义(P>0.05)。治疗后,全部患者APACHEⅡ评分、CRP、WBC、血液流变指标、D-dimer、PT与APTT水平均明显低于治疗前,且观察组明显低于对照组(P<0.05);全部患者PLT、FIB水平明显高于治疗前,且观察组明显高于对照组(P<0.05)。两组患者药物不良反应率比较差异无统计学意义。结论:低分子肝素钠治疗脓毒症患者的临床疗效显著,有助于改善血液流变性,并纠正凝血活化与凝血功能紊乱。

Objective：To investigate the effect of low molecular weight heparin sodium（LMWHs） on blood viscosity and coagulation parameters of patients with sepsis.Methods：Sixty cases of patients with sepsis were randomly divided into a control group and an observation group with 30 cases each.The control group was treated with conventional therapy and the observation group with LMWHs on the base of the control group.The clinical efficacy,blood viscosity and coagulation parameters were compared between two groups.Results：APACHE II score,CRP,WBC,blood viscosity indexes and coagulation parameters in two groups had no statistically significant difference（P〈0.05） before treatment,however,the indexes mentioned above as well as the levels of D-dimer,PT and APTT in all the patients were significantly improved after treatment,and they were significantly lower in the observation group than in the control group（P〈0.05）.PLT and FIB levels in all the patients were significantly higher post-therapy than pre-therapy and in the observation group than in the control group（P〈0.05）.There were no significant differences in adverse drug reactions between two groups.Conclusion：LMWHs has significant clinical effect on patients with sepsis,can improve blood viscosity and correct the activation and disorders of coagulation.