Ducks’B期直肠癌淋巴结中的GCCmRNA表达与预后的关系

Relationship between lymph node GCC mRNA expression and prognosis in stage Ducks'B Rectal cancer

目的探讨GCCm RNA在Ducks’B期直肠癌淋巴结中表达与预后的关系及能否作为判定淋巴隐匿性转移的有效指标。方法应用RT-PCR检测33例Ducks’B期直肠癌淋巴结中GCCm RNA表达水平,并分析患者的局部复发率、3年无瘤生存率(PFS)、3年总生存率(OS)与不同GCCm RNA表达水平的关系。结果 GCCm RNA阴性组患者的局部复发率和远处转移率更低(P<0.01),无瘤生存率与总生存率更高(P<0.01)。结论 GCCm RNA不同表达状态Ducks’B期直肠癌患者的预后有差异,GCCm RNA可以作为直肠癌淋巴结微转移的有效检测指标,可以作为甄别p N0直肠癌高危患者的可靠分子学指标,有利于高危患者后续辅助治疗的选择。

Objective To explore the relationship between GCC mRNA expression of lymph nodes and prognosis in stage Ducks＇B Rectal Cancer patients. Method The expression of GCC mRNA in lymph nodes of 33 stage Ducks＇B Rectal Cancer pa- tients were detected by RT-PCR method,they were divided into the GCC mRNA positive group for 14 cases and the negative groups for 19 cases. The relationship between local recurrence,distant metastasis rate,disease-free survival of 3 years （DFS）, over-all survival （OS） and GCC mRNA expression levels of the two groups were analyzed. Results The GCC mRNA negative group had lower local recurrence and distant metastasis rate （P〈0.05）,and longer disease-free survival （P〈0.05）. Conclusion Lymph node GCC mRNA expression level is closely related to the prognosis of stage Ducks＇B rectal cancer patient. It can be used as an effective molecular marker in lymph node micrometastase of rectal cancer.