耐力训练对心肌PERK/eIF2α/ATF4信号通路激活的影响

Effects of Endurance Exercise Training on PERK/eIF2α/ATF4 Signaling Pathway in Cardiac Muscle

探讨内质网应激机制在耐力训练对心肌功能影响过程中的作用。方法:通过建立不同运动方式、运动训练状态和不同恢复阶段的动物模型,测定心肌中与内质网应激相关的信号通路PERK/eIF2α/ATF4激活水平的变化。结果:无论是急性运动,还是4或10周的递增负荷耐力训练,都没有显著激活PERK/eIF2α/ATF4信号通路,但是以延长运动时间为特征的耐力训练能够激活PERK/eIF2α/ATF4信号通路。结论:以递增运动时间为特征的耐力训练能够激活PERK/eIF2α/ATF4信号通路,该通路的激活对运动心肌的结构和功能变化可能产生影响。

This study sets to investigate the effect of endurance training on the cardiac muscles,and identify if endoplasmic reticulum stress is involved in the process of functional and structural changes.Methods：We established animal models of different exercise types,training status,and recovery periods in order to study the activation of PERK/eIF2α/ATF4 signaling pathway.Results：Neither a single bout nor 4or 10 weeks of endurance training induced the activation of PERK/eIF2α/ATF4 signaling pathway.However,duration-increased endurance training significantly activated the activation of PERK/eIF2α/ATF4 signaling pathway.Conclusion：Endurance exercise that characterized with durance increase induced the activation of PERK/eIF2α/ATF4 signaling pathway that might play role in the process of functional and structural changes.