Protection of Calcitonin Gene-Related Peptide-Induced Preconditioning against Myocardial Injury due to Adriamycin in the Isolated Rat Heart *

降钙素基因相关肽预处置对阿霉素所致离体大鼠心脏损伤的保护作用

The protective effect of calcitonin gene-related peptide (CGRP)-induced preconditioning on myocardial injury due to adriamycin was studied in the isolated perfused rat heart. Adriamycin (100 and 200 (mol / L) caused a gradual decrease in coronary flow (CF) and cardiac function (LVP and LV dp/dtmax), and an increase in the level of MDA. Pretreatment with CGRP at the concentration of 5 nmol/L for 5 min markedly reduced the attenuation of CF and cardiac function and inhibited the elevation of MDA content induced by adriamycin. The findings suggest that the pretreatment with CGRP possesses a protection against myocardial injury elicited by adriamycin. The present results also suggest that the protection of CGRP may be related to a reduction in lipid peroxidation.

在离体灌流大鼠心脏研究了降钙素基因相关肽（ＣＧＲＰ）预处置对阿霉素所致心肌损伤的保护作用。阿霉素（１００和２００（ｍｏｌ／Ｌ）导致冠脉流量减少，心脏功能降低和丙二醛（ＭＤＡ）含量的升高。ＣＧＲＰ（５ｎｍｏｌ／Ｌ）灌流预处置５分钟能增加冠脉流量，改善心脏功能及抑制ＭＤＡ的升高。这些结果提示：ＣＧＲＰ预处置对阿霉素所致的心脏损伤具有保护作用。