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思美泰联合苦黄注射液治疗淤胆型肝炎疗效观察及对肝功能的影响 被引量:3

Curative Effect of Transmetil Combined with Kuhuang Injection for Cholestatic Hepatit and Effect on Liver Function
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摘要 目的:观察淤胆型肝炎患者采用思美泰联合苦黄注射液治疗的临床疗效,同时观察其对患者肝功能的改善效果。方法:将本院肝科病房150例患者随机分为2组,对照组62例采用苦黄注射液治疗,治疗组88例于对照组治疗方案的基础上加用思美泰,2组均给予护肝治疗。观察2组患者治疗前后肝功能各项指标变化情况,统计2组患者血清胆红素下降至正常5倍内的时间,并统计2组临床疗效及治疗期间所发生的不良反应情况。结果:治疗后,2组患者天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、直接胆红素(DBil)、碱性磷酸酶(ALP)、总胆红素(TBil)、γ-谷氨酰转肽酶(GGT)及总胆汁酸(TBA)水平较治疗前下降,且白蛋白(Alb)及胆碱酯酶(CHE)较治疗前升高,差异均有统计学意义(P<0.05);治疗组各项指标改善较对照组显著,差异均有统计学意义(P<0.05)。总有效率治疗组96.6%(85/88),高于对照组75.8%(47/62),差异有统计学意义(P<0.05)。治疗组血清胆红素下降至正常5倍内的平均时间为(12.7±6.8)天,低于对照组(17.5±7.9)天,差异有统计学意义(P<0.05),治疗期间无明显不良反应。结论:应用思美泰联合苦黄注射液治疗淤胆型肝炎疗效显著且安全。 Objective:To observe the clinical effect of transmetil combined with Kuhuang injection for cholestatic hepatitis patients and meanwhile to observe the improving effect on liver function. Methods:One hundred and fifty cases of patients were divided into two groups randomly. Sixty- two patients in the control group were given Kuhuang injection,while the 88 patients in the treatment group were given transmetil on the basis of treatment in the control group. Patients in both groups were given the liver protection treatment. Observe indexes change of the liver function of patients in two groups before and after treatment and calculate the time of the serum bilirubin declining to the 5 times of the normal value in two groups. Record the clinical effect and adverse reaction of two groups during the treatment period. Results:After treatment,the levels of aminotransferase(ALT),aspartate aminotransferase(AST),gamma- glutarmyl transpeptidase(GGT),direct bilirubin(DBil),total bilirubin(TBil),alkaline phosphatase(ALP) and total biliary acid(TBA) were all dropped(P0.05 compared with before treatment),and the levels of albumin(Alb)and Cholinesterase(CHE) were improved(P〈0.05 compared with before treatment). The improvement of each index in the treatment group was more obvious than that in the control group(P〈0.05). The total effective rate in the treatment group was 96.6%(85/88),and was higher than that of 75.8%(47/62) in the control group(P0.05). Comparing the average time of the serum bilirubin declining to the 5 times of the normal value, the results in the treatment group was(12.7±6.8) days,and was obviously less than that of(17.5±7.9) days in the control group(P0.05).There was no obvious adverse reaction during treatment course. Conclusion:The curative effect of transmetil combined with Kuhuang injection for cholestatic hepatitis is significant and safe.
作者 应茵 吴波明
出处 《新中医》 CAS 2016年第6期63-65,共3页 New Chinese Medicine
基金 中国肝炎防治基金会天晴肝病研究基金项目(CFHPC20132074)
关键词 淤胆型肝炎 苦黄注射液 思美泰 肝功能 天门氨酸转氨酶 丙氨酸转氨酸 直接胆红素 碱性磷酸酶 总胆红素 Cholestatic hepatitis Kuhuang injection Transmetil Liver function Aspartate aminotransferase Aminotransferase Direct bilirubin Alkaline phosphatase Total bilirubin
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