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Decorin treatment for reversing trabecular meshwork fibrosis in open-angle glaucoma 被引量:3

Decorin treatment for reversing trabecular meshwork fibrosis in open-angle glaucoma
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摘要 In this perspective,we discuss the use of an anti-fibrotic agent Decorin to treat established fibrosis associated with glaucoma originally published by Hill et al.(2015).Glaucoma describes a group of progressive optic neuropathies that have the potential to cause irreversible blindness. In this perspective,we discuss the use of an anti-fibrotic agent Decorin to treat established fibrosis associated with glaucoma originally published by Hill et al.(2015).Glaucoma describes a group of progressive optic neuropathies that have the potential to cause irreversible blindness.
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第6期922-923,共2页 中国神经再生研究(英文版)
基金 funded by the Biotechnology and Biological Sciences Research Council(BBSRC),No.BB/F017553/1
关键词 glaucoma trabecular originally irreversible progressive optic outflow ganglion progression elevated glaucoma trabecular originally irreversible progressive optic outflow ganglion progression elevated
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  • 1Ahmed Z, Bansal D, Tizzard K, Surey S, Esmaeili M, Gonzalez AM, Berry M, Logan A (2014) Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds. Neurobiol Dis 64:163-176.
  • 2Battacharya SK, Gabelt BT, Ruiz J, Picciani R, Kaufman PL (2009) Cochlin expression in anterior segment organ culture models after TGFbeta2 treatment. Invest Ophthalmol Vis Sci 50:551-559.
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  • 4Botfield H, Gonzalez AM, Abdullah O, Skjolding AD, Berry M, McAllister JP 2nd, Logan A (2013) Decorin prevents the development of juvenile communicating hydrocephalus. Brain 136:2842-2858.
  • 5Grisanti S, Szurman P, Warga M, Kaczmarek R, Ziemssen F, Tatar O, Bartz-Schmidt KU (2005) Decorin modulates wound healing in experimental glaucoma filtration surgery: a pilot study. Invest Ophthalmol Vis Sci 46:191-196.
  • 6Goldoni S, Iozzo RV (2008) Tumor microenvironment: modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer 123:2473-2479.
  • 7Hill IJ, Mead B, Blanch RJ, Ahmed Z, De Cogan F, Morgan-Warren PJ, Mohamed S, Leadbeater W, Scott RA, Berry M, Logan A (2015) Decorin reduces intraocular pressure and retinal ganglion cell loss in rodents through fibrolysis of the scarred trabecular meshwork. Invest Ophthalmol Vis Sci 56:3743-3757.
  • 8Prendes MA, Harris A, Wirostko BM, Gerber AL, Siesky B (2013) The role of transforming growth factor β in glaucoma and the therapeutic implications. Br J Ophthalmol 97:680-686.
  • 9Robertson IV, Golesic E, Gauldie J, West-Mays JA (2010) Ocular gene transfer of active TGF-β induces changes in anterior segment morphology and elevated lOP in rats. Invest Ophthalmol Vis Sci 51:308- 318.
  • 10Seidler DG, Goldoni S, Agnew C, Cardi C, Thakur ML, Owens RT, MeQuillan DJ, Iozzo RV (2006) Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase- 3 activation. J Bioi Chern 281:26408-26418.

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