基于核壳型结构纳米粒子的SERS活性基底研究进展

A Review on the Fabrication of SERS-active Substrates Based on Core-shell Nanoparticles

表面增强拉曼光谱(Surface-enhanced Raman spectroscopy,SERS)作为一种新型分析检测技术,具有检测快速、灵敏度高、非破坏性、原位检测等优点。高灵敏度、高稳定性、高增强能力及高重复性、可循环利用的SERS活性基底的制备是获得较好SERS信号的一个重要因素。与传统的单一组分SERS基底相比,将多种不同功能的纳米材料进行复合,形成的核壳型结构纳米粒子作为一种新型SERS活性基底,不仅能获得更为稳定的SERS信号,还能赋予其富集分离、催化和特异性分子识别等功能。该文综述了近年来基于复合贵金属、磁性材料、半导体、复合有机等核壳型结构纳米粒子的SERS活性基底的研究进展。

As a new type of analysis and detection technique, surtace-enhanced Raman spectroscopy （SERS） has attracted more and more attention due to its unique properties of rapid delection, high sensitivity, non-destructive and the in-situ detection ability. Theretore, SERS has a great develop- ment potential and an application prospect as a spectral analysis technique. Recyclable SERS-active substrates with high sensitivity, highly enhanced intensity and good repeatability and stability have a great influence on the intensity of SERS signals. A variety of different functional nanomaterials can be composited through layer-by-layer, surface modification method and sonochemistry coating to form core-shell nanoparticles as novel SERS-aetive substrates. They can not only enhance the reproduc- ibility of SERS signal, but also maintain the stability of the core-shell nanoparticles in analysis. The conventional SERS substrates mainly include metal colloids, metal island films, chemical etched metal films, ete. However, those SERS substrates have the disadvantages of poor reproducibility and stability. In contrast to those traditional monocomponent SERS substrates, more stable SERS signals could be achieved by using core-shell nanoparticles with functions of enrichment and separation, ca- talysis and specific molecular recognition, which promote the further research of SERS theory and the application of SERS technology. In this review, recent advances of SERS-active substrates based on modified noble metal, magnetic nanocomposites, semiconductor, complex organic core-shell nanop- articles were reviewed.