胃癌术后替吉奥化疗与FP化疗对预后、影像学特征及血清标志含量的影响

Effect of S-1 chemotherapy and FP chemotherapy on prognosis,imaging characteristics and serum marker levels after operation for gastric carcinoma

目的:分析胃癌术后替吉奥化疗与FP化疗对预后、影像学特征及血清标志含量的影响。方法:68例接受根治性手术治疗的胃癌患者被纳入研究,随机分为观察组及对照组各34例。对照组接受FP化疗,观察组接受替吉奥化疗,对比两组血清肿瘤标记物、病情相关因子、营养指标及T细胞免疫功能值等差异。结果:观察组接受系统化疗后,血清MMP-9、MMP-2、MG7-Ag、TSGF、CA72-4、CA19-9、TP、DpD等肿瘤标志物,DKK1、MK、Leptin、Exosome、OPN等病情相关因子,均低于对照组(P<0.05);TP、ALB、PA、CD4^+T、CD4^+T/CD8^+T值等营养及细胞免疫功能值高于对照组,CD8^+T值低于对照组(P<0.05)。结论:胃癌术后替吉奥化疗可以抑制肿瘤活性、优化患者整体病情,具有积极的临床意义。

[ABSTRACT]Objective：To analyze the effects of S-1 chemotherapy and FP chemotherapy on prognosis,imaging charac-teristics and serum marker levels after operation for gastric carcinoma.Methods：A total of 68 patients with gastric cancer who underwent radical surgery were included in the study and divided into observation group and control group patients （n =34）ac-cording to random number table.Control group received FP chemotherapy,observation group received S-1 chemotherapy,and then differences in serum tumor markers,illness-related factors,nutrition indexes and T cell immune function values were compared between two groups.Results：After observation group received systematic chemotherapy,serum tumor markers such as MMP-9,MMP-2,MG7-Ag,TSGF,CA72-4,CA1 9-9,TP and DpD as well as illness-related factors such as DKK1,MK, Leptin,Exosome and OPN were all lower than those of control group （P 〈0.05）;nutrition and cellular immune function inde-xes such as TP,ALB,PA,CD4 ＋ T and CD4 ＋ T/CD8 ＋ T values were higher than those of control group and CD8 ＋ T valuenbsp;was lower than that of control group （P 〈0.05）.Conclusion：S-1 chemotherapy after operation for gastric carcinoma can inhibit the tumor activity and optimize patients’overall condition,and it has positive clinical significance.