摘要
Hyphenrones R–X(1–7), seven new polyprenylated acylphloroglucinols derivatives, were isolated from the fruits of Hypericum henryi, together with eight know analogues. Compounds 1 and 2 were elucidated to possess complex caged skeleton, while compounds 3–6 shared a common 3,9-epoxy moiety deriving from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core. The new structures were elucidated on the basis of the interpretation of nuclear magnetic resonance(NMR) data, circular dichroism(CD) comparison, and single-crystal X-ray diffraction. In the bioassay, several compounds exhibited inhibitory activities against human tumor cell lines in vitro.
Hyphenrones R-X （1-7）, seven new polyprenylated acylphloroglucinols derivatives, were isolated from the fruits of Hypericum henryi, together with eight know analogues. Compounds 1 and 2 were elucidated to possess complex caged skeleton, while compounds 3-6 shared a common 3,9-epoxy moiety deriving from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core. The new structures were elucidated on the basis of the interpretation of nuclear magnetic resonance （NMR） data, circular dichroism （CD） comparison, and single-crystal X-ray diffraction. In the bioassay, several compounds exhibited inhibitory activities against human tumor cell lines in vitro.
作者
Yang Liao
Shu-Ya Yang
Xiao-Nian Li
Xing-Wei Yang
Gang Xu
Yang Liao;Shu-Ya Yang;Xiao-Nian Li;Xing-Wei Yang;Gang Xu(State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;University of Chinese Academy of Sciences, Beijing 100049, China)
基金
supported by the Natural Sciences Foundation of Yunnan Province (2015FA032)
Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2015-ZZ07)
the foundation from Youth Innovation Promotion Association CAS to X.W. Yang and G. Xu
the West Light Foundation of the Chinese Academy of Sciences to X.W. Yang
