H型高血压患者采用半夏白术天麻汤加减综合治疗对改善血压及血浆Hcy的影响

H Type Hypertensive Patients Using Banxia Baizhu Tianma Decoction Combined Therapy to Improve Blood Pressure and Plasma Hcy

目的:探讨半夏白术天麻汤加减综合治疗H型高血压患者临床疗效,并观察其对患者血压及血浆hcy等指标的影响。方法:回顾性分析2013年6月—2015年6月100例诊断为H型高血压患者临床资料,按照随机数字表法分组为对照组(马来酸依那普利叶酸片,10 mg/d)与观察组(于对照组治疗基础上加用半夏白术天麻汤加减治疗),各50例。于治疗前、后分别检测两组患者Hcy、叶酸及维生素B12水平、血清炎症因子水平、内皮功能情况。比较两组患者治疗前、后血压变化,统计治疗期间不良反应情况。结果:治疗后,两组患者Hcy、叶酸及维生素B12、血清炎症因子水平及内皮功能较治疗前明显改善,然观察组改善程度较对照组显著,P<0.05。治疗后,两组患者收缩压(SBP)及舒张压(DBP)较治疗前显著下降,然观察组下降程度较对照组显著,P<0.05。治疗期间,两组均未见明显不良反应。结论:应用马来酸依那普利叶酸片联合半夏白术天麻汤加减治疗H型高血压患者可显著降低血压及血清Hcy水平,提高叶酸水平及缓解炎性因反应,从而有利于其血管内皮功能改善。

Objective：To investigate the clinical efficacy Banxia Baizhu Tianma Tianma Decoction combined therapy on H type hypertensive patients and observe its effect on blood pressure and plasma Hcy other indicators. Methods： It is a retrospective analysis. In our hospital during June 2013--June 2015,100 cases diagnosed as H type hypertension were randomly grouped into control group （enalapril maleate folic acid tablets, 10 mg/d） and observation group （the control group therapy combined with Banxia Baizhu Tianma Decoction） ,50 cases in each. Before and after treatment, we detected two groups＇ Hcy,folate and vitamin B12 levels,serum levels of inflammatory cytokines and endothelial function situation. Before and after treatment compare two groups＇ changes in blood pressure and adverse reactions during treatment statis- tics. Results： After treatment, two groups＇ Hcy, folic acid and vitamin B12, serum levels of inflammatory factors and endo- thelial function significantly improved and then the degree of improvement in observation group was better than the control group＇s significantly,P 〈 0.05. After treatment, the two groups＇ systolic blood pressure（SBP） and diastolic blood pres- sure（DBP） were decreased significantly and then the extent of the observation group was significantly decreased compared with that of the control group ,P 〈 0.05. During treatment, the two groups showed no significant adverse reactions. Con- clusion ： Application of enalapril maleate folic acid tablets combined with Banxia Baizhu Tianma Decoction for treatment of H type hypertensive patients can significantly lower blood pressure and serum Hcy level to improve the level of folic acid and relieve inflammatory reaction to improve the vascular endothelial function.