前列腺素E1联合糖皮质激素治疗药物性重症肝炎的临床效果

Clinical Effects of Prostaglandin E1 combined with Glucocorticoid Hormone on the Treatment of Severe Hepatitis with Drugs

目的:探讨前列腺素E1联合糖皮质激素治疗药物性重症肝炎的临床效果。方法:前瞻性研究我院药物性重症肝炎患者68例,随机分为实验组与对照组,每组34例。对照组患者给予糖皮质激素治疗,实验组患者给予糖皮质激素联合前列腺素E1治疗。观察并比较治疗前后两组患者血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)水平的变化情况,以及临床疗效和并发症的发生率。结果:与治疗前相比,两组患者治疗后血清ALT,AST,TBIL水平均降低,差异具有统计学意义(P<0.05);与对照组相比,实验组患者治疗后血清ALT,AST及TBIL水平较低,差异具有统计学意义(P<0.05);实验组患者并发症发生率(41.18%)明显低于对照组(52.94%),差异具有统计学意义(P<0.05)。实验组患者临床总有效率(91.18%)显著高于对照组(73.53%),差异具有统计学意义(P<0.05)。结论:前列腺素E1联合糖皮质激素能够提高药物性重症肝炎的临床总有效率,降低并发症发病率,值得在临床上推广应用。

Objective： To investigate the clinical effects of prostaglandin E1 combined with glucocorticoid hormone on the treatment of severe hepatitis with drugs. Methods： Prospective study of 68 patients with severe drugs hepatitis were collected and randomly divided into the experiment group and the control group, with 34 cases in each group. The patients in the control group were treated with glucocorticoid hormone, while the patients in the experiment group were treated with the glucocorticoid hormone and prostaglandin E1.Then the serum levels of alanine aminotransferase（ALT）, aspartate aminotransferase（AST） and total bilirubin（TBIL）, and the clinical effective rate and incidence of complications in the two groups. Were observed and compared between the two groups. Results： Compared with before treatment, the serum levels of ALT, AST and TBIL in the two groups decreased after the treatment, and the differences were statistically significant（P〈0.05）; Compared with the control group after the treatment, the serum levels of ALT, AST and TBIL in the experiment group were lower, and the differences were statistically significant（P〈0.05）; The incidence of complications in the experiment group was 41.18%, which was lower than 52.94% in the control group, and the difference was statistically significant（P〈0.05）; The total effective rate in the experiment group was 91.18%, which was higher than 73.53% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion： Prostaglandin E1 combine with glucocorticoid hormone has better effects on the treatment of severe hepatitis induced by drugs, which can improve the total effective rate and reduce the incidence of complications, and it is worthy of clinical application.