长期应用马来酸依那普利叶酸片治疗H型高血压伴慢性心力衰竭患者的安全性研究

Safety of chronic oral-taking enalapril maleate and folic acid tablets in the treatment of H-type hypertension with chronic heart failure

目的 探讨长期应用马来酸依那普利叶酸片治疗H型高血压伴慢性心力衰竭患者的安全性。方法 选取2014年3月～2015年12月H型高血压伴有慢性心力衰竭患者50例,在常规治疗基础上服用马来酸依那普利叶酸片,剂量从每日5.0 mg/0.4 mg开始,每2周递增1次,直至靶剂量或最大耐受剂量。观察加用马来酸依那普利叶酸片后6、12个月时临床疗效、血压状态、心功能情况与不良反应。结果 加用马来酸依那普利叶酸片治疗6、12个月后血压下降且平稳,心力衰竭症状减轻,心功能明显改善,且治疗12个月较治疗6个月改善更加明显（P〈0.05）。未发现明显的药物不良反应,血小板、血红蛋白、肝肾功能均无显著影响（P〉0.05）。结论 长期口服马来酸依那普利叶酸片治疗H型高血压伴慢性心力衰竭具有显著的临床疗效,且有较高的安全性,可提高患者生活质量,提高生存率。

Objective To explore the safety of enalapril maleate and folic acid tablets in patients with H-type hypertension complicated with chronic heart failure.Methods 50 patients with H-type hypertension complicated with chronic heart failure from March 2014 to December 2015 were selected,on the base of regular treatment,they were taken enalapril maleate and folic acid tablets,the starting dose of 5.0 mg/0.4 mg,once every 2 weeks,the dose of was increased to the target dose or maximal tolerated.Treatment effect,blood pressure state,heart function and adverse drug reaction were observed before treatment and after treatment for 6 and 12 months.Results Clinical symptoms improved markedly in patients with H-type hypertension complicated with chronic heart failure after treatment for 6 and 12 months with enalapril maleate and folic acid tablets（P〈0.05）;no significant adverse drug reactions,platelet hemoglobin liver kidney function had no significant influence.Conclusion Treatment with enalapril maleate and folic acid tablets for patients with H-type hypertension complicated with chronic heart failure can markedly improve the safety and survival rate.