DMAc促进乙酰苯胺的合成

Dimethylacetamide-promoted Synthesis of N-acetyl Anilines

在N,N-二甲基乙酰胺(DMAc)和CH2Cl2体系中,乙酸与SOCl_2在0℃下反应20 min,制得的乙酰氯不经提纯直接与加入的苯胺在25℃下反应5 h,得到了一系列取代乙酰苯胺化合物。优化条件下,反应产率为83%~97%。目标化合物的结构经~1HNMR、^(13)CNMR、IR和MS确证,提出了DMAc协同促进乙酰苯胺合成反应的可能机理。

A series of N-acetyl anilines were synthesized by the chlorination of acetic acid with thionyl chloride in dimethylacetamide-dichloromethane at 0 ℃ for 20 min,followed by amidation in situ with anilines at 25 ℃ for 5 h in 83%-97% yields under the optimal conditions.The structures of target compounds were confirmed by ^1HNMR,^13CNMR,IR and MS.The proposed mechanism for the promotion of dimethylacetamid on the synthesis was suggested.