缩宫素联合欣母沛在瘢痕子宫产后出血及憩室中的预防效果及安全性研究

Study of the Prevention Effect and Safety of Oxytocin Joint Hemabate in Postpartum Hemorrhage of Scar Uterus and Diverticulum

目的:探讨缩宫素联合欣母沛在瘢痕子宫产后出血及憩室中的预防效果及安全性。方法:选取2014年5月-2016年6月在医院接受治疗的120例瘢痕子宫产后出血及憩室产妇作为研究对象,并将其随机分为观察组与对照组,每组60例。对照组产妇给予缩宫素进行治疗,观察组产妇在对照组的基础上联合欣母沛进行治疗,观察两组产妇临床症状的变化情况,分析比较两组产妇术中出血量、术后2 h出血量、产后24 h出血量、产后出血率、不良反应发生情况。结果:观察组产妇术中出血量、术后2 h出血量、产后24 h出血量情况改善程度均明显优于对照组,差异均有统计学意义(P<0.05);观察组产后出血率为6.7%,明显低于对照组的23.3%,差异有统计学意义(P<0.05);观察组不良反应发生率为3.3%,低于对照组的13.3%,差异有统计学意义(P<0.05)。结论:缩宫素联合欣母沛在瘢痕子宫产后出血及憩室的应用效果显著,有效改善了临床症状,降低了产后出血率,提高了安全性,临床上值得应用。

Objective：To study the prevention effect and safety of Oxytocin combined with Hemabate in postpartum hemorrhage of scars uterus and diverticulum.Method：120 parturient women with postpartum hemorrhage and diverticulum in our hospital from May 2014 to June 2016 were selected as research objects,they were randomly divided into observation group and control group,60 cases in each group.The control group was given oxytocin treatment,the observation group in the control group on the basis of joint hemabate treatment,the changes of clinical symptoms were observed in two groups,the blood loss,the amount of bleeding after operation,the amount of bleeding after 2 h,the amount of postpartum hemorrhage of 24 h,the rate of postpartum hemorrhage,the incidence of adverse reactions in the two groups were analyzed and observed.Result：In the observation group,the amount of bleeding in the operation,the amount of bleeding after 2 h,postpartum hemorrhage volume of the improvement of the 24 h were significantly better than those in control group,the differences were statistically significant（P〈0.05）.The rate of postpartum hemorrhage in the observation group was 6.7%,which was significantly lower than 23.3% of the control group,the difference was statistically significant（P〈0.05）.The incidence of adverse reactions in observation group was 3.3%,which was lower than 13.3%in control group,the difference was statistically significant（P〈0.05）.Conclusion：The application effect of Oxytocin joint Hemabate in postpartum hemorrhage of uterine scar and diverticulum is significant,effectively improve clinical symptoms,reduce the rate of postpartum hemorrhage,improve safety,and is worthy of clinical application.