摘要
The novel 1,2-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones were selectively synthesized in high yields by the base catalyzed cyclization reaction of 3-arylamino-l-methyl-lH-pyrrole-2,5-diones with cinnamaldehyde and its derivatives in acetonitrile at room temperature. However, when piperidinium trifluoroacetate was employed as catalyst, the reaction afforded a mixture of 1,2-diaryl and 1,4-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones in comparable yields.
The novel 1,2-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones were selectively synthesized in high yields by the base catalyzed cyclization reaction of 3-arylamino-l-methyl-lH-pyrrole-2,5-diones with cinnamaldehyde and its derivatives in acetonitrile at room temperature. However, when piperidinium trifluoroacetate was employed as catalyst, the reaction afforded a mixture of 1,2-diaryl and 1,4-diaryl substituted pyrrolo[3,4-b]pyridine-5,7-diones in comparable yields.
