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Red-blood-cell-shaped chitosan microparticles prepared by electrospraying 被引量:4

Red-blood-cell-shaped chitosan microparticles prepared by electrospraying
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摘要 Red-blood-cell-shaped chitosan microparticles with acid-triggered dissolution and auto-fluorescence were successfully fabricated by a simple strategy combining electrospraying with a solvent diffusion process controlled by solvent evaporation. The sizes of the prepared chitosan microparticles were rela- tively uniform. Control of the solvent diffusion process was crucial for the formation of microparticles with concave morphology. A chitosan aqueous solution containing 20vo1% ethanol as the evaporable solvent and 30 vol% dimethyl sulfoxide as the diffusible solvent was optimal for preparation of chitosan microparticles with the desired red-blood-cell-like size and shape. These chitosan microparticles will be highly attractive for many biological and biomedical aoolications. Red-blood-cell-shaped chitosan microparticles with acid-triggered dissolution and auto-fluorescence were successfully fabricated by a simple strategy combining electrospraying with a solvent diffusion process controlled by solvent evaporation. The sizes of the prepared chitosan microparticles were rela- tively uniform. Control of the solvent diffusion process was crucial for the formation of microparticles with concave morphology. A chitosan aqueous solution containing 20vo1% ethanol as the evaporable solvent and 30 vol% dimethyl sulfoxide as the diffusible solvent was optimal for preparation of chitosan microparticles with the desired red-blood-cell-like size and shape. These chitosan microparticles will be highly attractive for many biological and biomedical aoolications.
出处 《Particuology》 SCIE EI CAS CSCD 2017年第1期151-157,共7页 颗粒学报(英文版)
关键词 Chitosan microparticle Red blood cell Electrospraying Solvent evaporation Solvent diffusion Chitosan microparticle Red blood cell Electrospraying Solvent evaporation Solvent diffusion
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