消定膏对膝骨关节炎IL-1β、TNF-α的影响

Effect of Xiaoding Ointment on IL-1β and TNF-α in Patients with Knee Osteoarthritis

目的:探讨消定膏治疗膝骨关节炎的机制。方法:将膝骨关节炎106例分为2组各53例,治疗组给予消定膏治疗,对照组给予奇正消痛贴膏治疗,疗程2周。采用酶联免疫吸附测定法(ELISA)检测膝关节液标本中白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的含量。结果:治疗前以及治疗后2组间IL-1β、TNF-α比较,差异无统计学意义(P>0.05)。经治疗,2组关节液IL-1β、TNF-α浓度均下降(P<0.05)。结论:消定膏可能是通过降低关节液中IL-1β、TNF-α的含量来发挥对膝骨关节炎的治疗作用。

Objective：To observe the mechanism of Xiaoding ointment in treating knee osteoarthritis.Methods：Divided160 cases of patients with knee osteoarthritis into two groups randomly,53 cases in each group.The treatment group was treated with Xiaoding ointment,while the control group was treated with Qizheng Xiaotong sticking plaster.The course lasted for two weeks.Determined contents of interleukin- 1β（IL-1β） and tumor necrosis factor-α（TNF-α） in joint fluid specimens by enzymic method and enzyme- linked immunosorbent assay（ELISA）.Results：Compared IL-1β and TNF-α in the two groups before and after treatment,no difference was significant（P〈0.05）.Concentrations of IL-1β and TNF-α in both groups were decreased after treatment（P〈0.05）.Conclusion：Xiaoding ointment may exert its curative effect for knee osteoarthritis by reducing the contents of IL-1β and TNF-α in joint fluid.