NK/T细胞淋巴瘤患者外周血EB病毒检测价值分析

Clinical Significance of Peripheral blood EB Virus Detection in NK/T Cell Lymphoma Patients

目的:探讨NK/T细胞淋巴瘤患者外周血EB病毒的检测价值。方法:检测85例NK/T细胞淋巴瘤患者EB病毒阳性情况以及EBV DNA载量,并分析EB病毒阳性与临床分期、短期预后、远期预后的相关性。结果:NK/T细胞淋巴瘤患者EB病毒阳性率较高,为80.0%;外周血白细胞EBV DNA拷贝数明显高于外周血血浆EBV DNA拷贝数(P<0.05),但外周血白细胞EBV DNA拷贝数与外周血血清EBV DNA拷贝数并无统计学差异(P>0.05);外周血血浆与外周血血清EBV DNA拷贝数并无统计学差异(P>0.05);EBV+组患者Ann Arbor分期Ⅰ-Ⅱ期患者所占比例明显低于EBV-组(P<0.05),而Ⅲ-Ⅳ期所占比例明显高于EBV-组(P<0.05);EBV+组患者CR率和ORR及3年总生存率和3年无进展生存率均明显低于EBV-组(P<0.05)。结论:外周血EB病毒检测可作为辅助诊断NK/T细胞淋巴瘤和评估患者预后的参考指标,有一定的临床应用价值。

Objective：To explore the clinical significance of peripheral blood EB virus detection in NK/T cell lymphoma patients. Methods：The positive rate of EB virus and EBV-DNA in 85 cases of NK/T cell lymphoma was assayed; the correlation of positive rate of EB virus with clinical staging, short-term and long-term prognosis was analyzed. Results：The positive rate of EB virus in NK/T cell lymphoma was high （80.00%）. The EBV - DNA copy number in peripheral blood leukocytes was higher than that in peripheral plasma （ P 〈 0.05 ）, but there was no significant difference in EBV^- DNA level between peripheral leukocytes and serum （ P 〉 0.05 ）. The Ⅰ-Ⅱ stages ratio of patients in EBV^＋ group was significantly lower than that in EBV^- group. The CR rate and ORR in EBV^＋ group was significantly lower than those in EBV^- group, the 3 year OS rate and 3 year DFR in EBV^- group also was significantly lower than those in EBV^- group. Conclusion： The detection of periphera blood EBV may be used as an reference indicator for anxiliary diagnosis of NK/T cell lymphoma and evaluation of prognosis for patients, thus possessing a certain value for clinical application.