马来酸曲美布汀片对溃疡性结肠炎患者血清TNF-α、IL-23、ESR、D-D的影响

Effect of trimebutine maleate tablets on serum TNF-α, IL-23, ESR, D-D ulcerative colitis in patients with ulcerative colitis

目的 分析马来酸曲美布汀片对溃疡性结肠炎患者血清肿瘤坏死因子（TNF）-α、白介素（IL）-23、红细胞沉积率（ESR）、D-二聚体（D-D）的影响,以期探索治疗溃疡性结肠炎患者的优化方案。方法 选择2014年10月~2016年10月慈溪市人民医院接诊的92例溃疡性结肠炎患者,通过随机数表法观察组46例和对照组46例,对照组给予美沙拉嗪肠溶片治疗,观察组在此基础上,使用马来酸曲美布汀片治疗。治疗8周后,比较2组疾病活动指数（Sutherland DAI评分）、TNF-α、IL-23、ESR、D-D的变化以及临床疗效。结果 治疗后,观察组Sutherland DAI评分明显低于对照组（P〈0.05）;观察组TNF-α、IL-23均显著低于对照组（均P〈0.05）;观察组ESR、D-D均显著低于对照组（均P〈0.05）;观察组临床疗效总有效率明显高于对照组[93.48%（43/46）vs.69.57%（32/46）]（P〈0.05）。结论 在溃疡性结肠炎患者中应用马来酸曲美布汀联合美沙拉嗪肠溶片治疗效果更显著,可有效降低机体炎症反应,改善高凝状态,促进病情恢复,值得应用推广。

[Abstract] Objective To study the effect of Trimebutine maleate tablets on serum tumor necrosis factor （TNF）-α, interleukin （ IL）-23, erythrocyte sedimentation rate（ESR） , D-dimer（D-D） ulcerative colitis in patients with ulcerative colitis. Methods 9 2 patients of ulcerative colitis w h o received therapy from October 2014 to October 2016 in our hospital were selected. According to random number table, those patients were divided into the observation group （ n, = 46 ） and the control group （ n, = 46 ） . The control group was treated with mesalazine slow release tablets, while the observation group was treated with trimebutine maleate tablets on this basis. After 8 weeks of treatment, the changes of the disease activity index （ Sutherland DAI score） , TNF-α, IL-23, ESR, D-D and clinical effect were compared. Results A f t e r t r e a t m e n t , the S u t h e r l a n d DAI s c o r e in the o b s e r v a t i o n g r o u p w a s significantly lower than that of the control group DAI（P 〈0. 05） ; the TNF-aand I L - 2 3 in the o b s e r v a t i o n g r o u p w e r e significantly l o w e r t h a n that of the control group （ all P 〈 0. 05 ） ; the ESR and D-D in the observation group were significantly lower than that of the control group （all P〈0. 05） ; the total effective rate in the observation group was significantly higher than that of the control group [93. 48% （43/46） vs. 69. 57% （32/46） ] （P 〈 0. 05）. Conclusion Trimebutine maleate tablets is well for ulcerative colitis, which can effectively reduce inflammation, improve hypercoagulable state, promote the recovery of the disease, it is worthy of application and promotion.