喜炎平注射液联合蒙脱石散治疗小儿轮状病毒性腹泻的疗效观察

Effect of Xiyanping injection combined with montmorillonite power on the treatment of rotavirus enteritis in children

目的观察喜炎平注射液联合蒙脱石散治疗小儿轮状病毒性腹泻的临床疗效。方法将该院2014-10~2016-05收治的84例轮状病毒性腹泻患儿随机分为观察组和对照组各42例,对照组在常规治疗基础上给予利巴韦林,观察组则给予喜炎平加蒙脱石散,连续治疗5~7 d。比较两组患儿主要症状持续时间及住院时间、不良反应情况、临床疗效。结果观察组患儿发热、呕吐、腹泻等主要症状的持续时间及住院时间均较对照组明显缩短(P<0.01)。观察组显效32例,有效8例,无效2例;对照组显效18例,有效15例,无效9例,观察组临床疗效明显优于对照组(P<0.05)。两组患儿治疗期间均未出现明显的不良反应。结论喜炎平注射液联合蒙脱石散治疗小儿轮状病毒性腹泻能缩短患儿病程,提高临床疗效,值得临床推广。

Objective To observe the effect of Xiyanping injection combined with montmorillonite power on the treatment of rotavirus enteritis in children. Methods Eighty-four children with rotavirus enteritis in our hospital from October 2014 to May 2016 were randomly divided into the observation group （n = 42） and the control group （n = 42）. On the basis of conventional therapy, the control group was treated with ribavirin, while the observation group received Xiyanping injection combined with montmorillonitc power. The duration of major symptoms, length of hospi- tal stay, adverse reactions and clinical effect were compared between the two groups. Results The duration of fever, vomiting, diarrhea and length of hospital stay in the observation group were significantly shorter than those in the con- trol group（P 〈 0. 01 ）. In the observation group, the clinical effect was markedly effective in 32 cases, effective in 8 cases, and ineffective in 2 eases. In the control group, the clinical result was markedly effective in 18 eases, effec- tive in 15 cases and ineffective in 9 cases. The clinical effect of the observation group was more excellent than that of the control group（P 〈 0. 05）. There were no obvious adverse reactions during therapy in both of the two group. Con- clusion Xiyanping injection combined with montmorillonite power can shorten the course of disease and improve the clinical efficacy in the treatment of rotavirus enteritis in children.