糖尿病大血管病变与调节性T细胞研究进展

Research Progress of Diabetic Macrovascular Disease and Regulatory T Cells

调节性T细胞(Treg)通过程序性细胞死亡分子1/程序性细胞死亡分子配体1(PD-1/PD-L1)通路诱导分泌相关细胞因子及肿瘤坏死因子,促使糖尿病的慢性炎症反应,大血管内皮细胞的损伤,并伴随长期高糖状态、糖基化终末产物等,亦导致2型糖尿病(T2DM)大血管病变的发生和发展。T2DM大血管病变可引起心脑血管事件,探讨应用药物阻断PD-1/PD-L1通路,影响相关细胞因子的分泌,重构Treg细胞免疫调节机制,可能延缓或阻断大血管病变进程的治疗方法,对于T2DM大血管病变的防治有重要意义。

Regulatory T cells（Treg） induce secretion of cytokines and tumor necrosis factor through programmed cell death-1/programmed cell death ligands-1 （PD-1/PD-L1） pathway ,promote chronic inflammatory reaction of diabetes, damage large vascular endothelial cells, forming long-term high glucose status, glycosylation end products, and f/nally leading to the occurrence and development of type 2 diabetes （T2DM） macrovascular disease. T2DM macrovascular disease can cause cardiovascular and cerebrovascular events,therefore studying using drugs to block PD-1/PD-L1 pathway to affect the secretion of related cytokines and remodel Treg cell immune regulation mechanism, to explore the possible delay or resistance treatment of large vascular disease process,is important for the prevention and treatment of T2DM macrovascular disease.