miR-17-92基因簇在肿瘤发生发展中作用的研究进展

Role of miR-17-92 gene cluster in tumor development and progression

肿瘤是威胁全世界人类健康和影响社会经济的重要因素.近年来,随着经济的发展,肿瘤的发病率呈明显上升趋势,但是其病因尚未完全阐明.越来越多的证据显示肿瘤的发生和遗传因素有关,随着病理生理学和遗传学的发展,许多学者认为生物标志物可以预测癌症甚至指导临床治疗.微小RNA(microRNA,miRNA)是非编码小分子RNA,在发育、生理、病理过程以及肿瘤发生等环节中起着重要的调节作用.miR-17-92基因簇是研究较为深入、最有特点的miRNA,被认为是原癌基因miRNA的代表,在多种肿瘤的发生发展中起着至关重要的作用.本文就miR-17-92基因簇在肿瘤发生发展中的作用及功能进行综述.

Tumors are an important factor that threatens human health and affects social economy.Although tumor incidence is increasing, their etiology is still not completely clear. Growing evidence has identified that genetic factors contribute to tumor development. Advances in the understanding of tumor pathophysiology and genetics suggest that genetic biomarkers can predict the future presence of tumors and even direct the approach to therapy.MicroRNAs are non-coding small RNA molecules that have vital effects on body development, physiological and pathological processes including tumorigenesis. MiR-17-92 gene cluster is a well-studied miRNA and considered to be oncogenic. It plays a signifi cant role in the development of a variety of tumors. In this paper, we will review the role of miR-17-92 gene cluster in the development and progression of tumors.