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高灵敏荧光定量PCR技术在乙肝患者中的应用分析

The Analysis of Application of High Sensitive Fluorescence Quantitative PCR Technique in Hepatitis B Patients
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摘要 目的研究高灵敏荧光定量PCR技术在乙肝患者中的应用效果。方法现研究选取的研究对象为2016年10月—2017年6月在我院进行治疗的乙肝患者923例和同期在本院进行体检的健康体检者200例。使用高灵敏荧光定量PCR技术检测两组受检者。结果不同血清标志物阳性乙肝患者的HBV-DNA拷贝数差异存在统计学意义(P<0.05),阳性率分别为35.97%、57.96%、6.07%,乙肝患者间进行比较差异具有统计学意义(P<0.05)。结论采用高灵敏荧光定量PCR技术可较好的诊出乙肝,还可监测治疗过程及评价药效。 Objective To study the effect of high sensitive fluorescence quantitative PCR in patients with hepatitis B. Methods 923 cases of hepatitis B patients treated in our hospital from October 2016 to June 2017, and 200 patients who had physical examination in our hospital during the same period were selected into the study. Two groups of patients were detected by high sensitive fluorescence quantitative PCR. Results There were differences in HBV-DNA copy number (P 〈 0.05), and the positive rate was 35.97%, 57.96% and 6.07%, and the difference between hepatitis B patients was signifcant (P 〈 0.05). Conclusion High sensitive fuorescence quantitative PCR technique can be used to diagnose hepatitis B, it can also monitor the treatment process and evaluate the effcacy.
出处 《中国卫生标准管理》 2017年第18期104-106,共3页 China Health Standard Management
基金 福州市卫计生科技计划项目(2016-S-wt9)
关键词 乙肝 高灵敏荧光定量PCR技术 应用效果 hepatitis B high sensitive fluorescence quantitative PCR technology application effect
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