格林-巴利综合征的临床、电生理、病理对照研究

Contrastive studies on clinical ,electrophysiological and pathological finding of GBS

目的 探讨格林-巴利综合征（GBS）的临床、电生理分型与病理改变相关性及治疗前后电生理动态改变特征及预后。方法 对45例GBS的临床、电生理改变特点和10例腓肠神经病理特征及5例电生理动态随访结果进行相关性、对照性研究。结果 本组病例电生理改变特点为:运动神经传导速度（MCV）和f波异常率大于感觉神经传导速度（SCV）异常率;绝大多数电生理改变符合脱髓鞘型损害（96％）,少数为轴索损害型（4％）。腓肠神经病理结果与电生理改变相符合。电生理动态随访显示:临床症状恢复早于电生理的恢复;MCV和EMG恢复较SCV快。结论 电生理检查除了作为GBS诊断重要手段之一,其电生理分型与其病理改变相吻合。可作为临床判断疗效和预后的客观指标之一及神经康复的动态随访指标。

Objective To investigate the relationship betweet clinical,electrophysiological types and patho-logical types of Guillain-Barre Syndrome (GBS). Methods The contrastive and comparative studies were done by analysing the features of clinical,electrophysiological and pathological change in 45 cases of GBS. Results Abnor-mal rate of MCV and f wave was more frequent than the one of SCV. Most of the electrophysiological findings con-form to demyelination types. Few cases conformed to axonal types. The pathological results of sarel nerve were the same as electrophysiological results. The electrophysiological trends observation showed clinical symptoms recov-ered earlier than SCV, MCV and EMG recovered more quickly than SCV. Conclusion The electrophysiological in-vestigation is an important mean to diagnose the GBS. It can be one of objective indications to evaluate the treat-ment result. Electrophysiological types conform to pathological types.