国医大师张学文教授治疗原发性高血压病肝热血瘀证用药规律研究

Study on Medication Rules of National Chinese Medicine Master Zhang Xuewen in Treating Primary Hypertension with Liver Heat and Blood Stasis Syndrome

目的应用中医传承辅助系统软件,挖掘分析张学文教授治疗原发性高血压病肝热血瘀证的用药规律。方法收集张学文教授近5年治疗原发性高血压病肝热血瘀证的病例,采用关联规则、系统熵聚类等数据挖掘方法,分析张学文教授治疗原发性高血压病肝热血瘀证的用药经验和用药规律。结果对筛选出的116首典型处方进行统计分析,得出处方中药物的使用频次、药物之间的关联规则、药物核心组合和新处方。结论张学文教授诊治原发性高血压病肝热血瘀证,以天麻钩藤饮和(或)脑清通汤为基础方加减,多用平肝熄风、活血化瘀药以治标,再加补肾、安神等药以扶正,标本兼治。

Objective To analyze the medication rule of Professor Zhang Xuewen in treatment of primary hypertension with liver heat and blood stasis syndrome by the software Traditional Chinese Medicine Inheritance Assistant System.Methods The primary hypertension cases with liver heat and blood stasis syndromes treated by Professor Zhang Xuewen in recent 5 years were collected,and the using regulation of medication and experience from Professor Zhang Xuewen in treating hypertension with liver heat and blood stasis syndrome were analyzed through data mining such as association rules and system entropy clustering.Results Statistical analysis of 116 typical prescriptions was carried out,and the frequency of drug use,the association rules among drugs,the core combination of drugs and the new prescriptions were obtained.Conclusion Professor Zhang Xuewen in treatment of primary hypertension with liver heat and blood stasis syndrome applied the therapy methods of clearing away liver heat and activating blood circulation,and used the Tianma Gouteng decoction and（or）Naoqingtong decoction as the basic prescription.Moreover,the symptoms were treated with the therapy of calming the liver to stop the wind and activating blood circulation to dissipate blood stasis,and the root of disease could be treated with medication of tonifying the kidney and tranquilizing the mind.