黄石地区2648例就诊者的HPV检测结果分析

Analysis of Epidemic Epidemiological Characteristics of Female HPV Infection Status of 2,648 Cases in Huangshi

为研究湖北省黄石地区女性人乳头瘤病毒(HPV)感染状况及其亚型分布,回顾性分析应用导流杂交基因芯片技术检测从2016年9月至2017年7月2 648例女性宫颈拭子HPV基因分型的结果,比较不同基因型的流行病学特点,并采用SPSS 17.0软件对数据进行统计分析。结果为:在2 648例检测标本中,检测出HPV阳性感染率为43.92%(1 163/2 648)。感染年龄分布以>60岁年龄段感染率最高,为63.46%;其次是≤20岁年龄段(47.56%);而后是21~30岁年龄段(47.39%),51~60岁年龄段(44.69%),41~50岁年龄段(42.87%),31~40岁年龄段(40.76%),各年龄组感染率之间无统计学差异(P>0.05)。20种HPV基因亚型中,居前5位的分别是HPV52(20.64%)、HPV16(14.70%)、HPV58(10.83%)、HPV6(6.45%)、HPV33(5.85%)。在不同宫颈病变的HPV感染状况中:宫颈炎组(24.38%)、CIN Ⅰ组(48.70%)、CIN Ⅱ组(77.89%)、CIN Ⅲ组(89.64%)、宫颈癌组(93.23%),两两比较有统计学意义(P<0.01)。单一型别占总感染例数的75.49%(878/1 163);多重感染率为24.51%(285/1 163),其中双重感染率为17.45%(203/1 163),三重以上混合感染率为7.05%(82/1 163)。湖北省黄石地区女性HPV感染率较高,应加强对HPV的筛检力度,为HPV相关疾病的防治提供重要参考。

Objective ： To investigate infection status and distribution of cervical human papillomavirus （HPV） in huangshi,hubei province. Methods：All 2,648 cases were studied. Cervical cell specimens and 20 hpv geno-types were analyzed by PCR and reverse dot blot gene chip technology. Results ： Total of 1 163 specimens were found with positive HPV among 2 648 cases,the positive rate was 43. 92% （1 163/2 648 ） . The infec-tion rate in 〉60 years old was the highest（63.46% ） ,next was2 0 years old（47.56% ） ,21 ~30 years old （47. 39% ） ,51 -60 years old（44. 69% ） ,41-50 years old（42. 87% ） ,31 ~40 years old（40. 76% ） . How-ever, there was no satistical difference among age groups （P 〉0.05） . 20 kinds of HPV gene subtype, the top five was respectively HPY52（20.64% ） ,HPY16 （14.70% ） ,HPY58（ 10. 83% ） ,HPY6 （6.45% ） ,HPY33 （5. 85%）. Different cervical lesions of HPY infection status were cervicitis group （24. 38%） , CIN I （48.70% ）,CIN II group（77. 89% ）,CIN III group（89. 64% ） ’cervical cancer（93. 23% ）,multiple com- parison among these was statistically significant（ P 〈0.01） . The infection rate of single subybe was 75.49% （878/1 163） , Multiple infection rate was 24. 51% （285/1 163）. With dual infection in 17. 45% （203 / 1 163） ,more than triple mixed infection rate was 7. 05% （82/1 163 ） . Conclusion; HPY infection rate is higher in Huangshi city,the HPY screening should be done and strengthened,which can provide a valuable reference for the prevention and treatment of HPY related disease.