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糖尿病前期和2型糖尿病与微血管功能障碍相关性研究 被引量:6

Association of pre diabetes and type 2 diabetes mellitus with microvascular dysfunction
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摘要 目的探讨糖尿病前期和2型糖尿病与微血管功能障碍的相关性。方法 2014年9月到2016年12月选择在我院诊治的2型糖尿病患者80例作为糖尿病组,同期选择在我院诊治的糖尿病前期患者80例作为糖尿病前期组,选择在我院进行体检的健康人80例作为对照组,三组都进行微血管功能障碍的判定,检测血液学指标PGI2和TXA2,超声测定E峰和A峰并进行相关性分析。结果糖尿病组中发生糖尿病视网膜病变11例,糖尿病肾病9例,糖尿病周围神经病变10例;糖尿病前期组中各发生3例、2例与1例,对比差异有统计学意义(P<0.05)。糖尿病组与糖尿病前期组的血清PGI2与TXA2水平都明显高于对照组,同时糖尿病组的血清PGI2与TXA2水平也高于糖尿病前期组(P<0.05)。糖尿病组与糖尿病前期组的E峰与A峰都明显高于对照组,同时糖尿病组的E峰与A峰也高于糖尿病前期组(P<0.05)。Pearson检验显示糖尿病组的微血管功能障碍与PGI2、TXA2、E峰、A峰都呈现明显相关性(P<0.05);糖尿病前期组的微血管功能障碍与PGI2、E峰呈现明显相关性(P<0.05)。结论糖尿病前期和2型糖尿病可导致微血管功能障碍发生率增加,诱发血栓形成与血管舒缩功能下降。 Objective To investigate the relationship between prediabetes and type 2 diabetes mellitus and microvas-cular dysfunction.Methods From September 2014 to December 2016,80 cases of patients with type 2 diabetes mellitus in our hospital were selected as diabetes group,and the other 80 patients with prediabetes were select at the same period in our hospital as the pre diabetes group,the 80 healthy people were examined in our hospital were selected as the con-trol group,three groups were to determine microvascular dysfunction,the hematological indexes of PGI2 and TXA2 were detected,and the E and A peaks were measured by ultrasound and correlation analysis.Results There were 11 ca-ses of diabetic retinopathy,9 cases of diabetic nephropathy,10 cases of diabetic peripheral neuropathy in the the diabetic group;so that were 3 cases,2 cases and 1 case in the pre diabetes group,there were statistically significant difference compared between the two groups(P 〈0.05).The levels of serum PGI2 and TXA2 in diabetic group and pre diabetes group were significantly higher than those in control group,and the serum levels of PGI2 and TXA2 in diabetic group were higher than those in pre diabetes group (P 〈0.05).The peaks of E and A in diabetic group and pre diabetes group were significantly higher than those in control group,and the peak of E and A in diabetic group was higher than that in pre diabetes group (P 〈 0.05).Pearson test showed that the microvascular dysfunction were related to the PGI2, TXA2,E and A peak in the diabetic group(P 〈0.05);and the microvascular dysfunction related to the PGI2,E peak in thepre diabetes group(P 〈0.05).Conclusion Pre diabetes and type 2 diabetes mellitus can lead to increase in the inci-dence of microvascular dysfunction that can result in inducing thrombosis and impairing vasomotor function.
作者 戚艳艳
出处 《中国实验诊断学》 2017年第12期2105-2108,共4页 Chinese Journal of Laboratory Diagnosis
基金 中央级公益性科研院所基本科研业务费专项资金项目(2014CS-27)
关键词 糖尿病前期 2型糖尿病 微血管功能障碍 Prediabetes type 2 diabetes mellitus microvascular dysfunction
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