益气养阴活血利水中药复方治疗视网膜脱离复位术后患者的疗效观察

Treatment of Patients with Retinal Detachment Surgery by Chinese Medicine Compound for Tonifying Qi,Nourishing Yin,Promoting Blood,and Alleviating Water Retention:Observation of Long Term Curative Effects

目的观察益气养阴活血利水中药复方治疗视网膜脱离复位术后患者的临床疗效。方法将786例视网膜脱离复位术后患者,随机分为益气养阴活血利水中药复方治疗组(中药复方组,265例)、益脉康片对照组(益脉康组,263例)和常规疗法对照组(常规组,258例)。各组患者在行视网膜脱离复位术后予常规抗炎、止血治疗,术后第2周始,中药复方组、益脉康组分别服用益气养阴活血利水中药复方、益脉康片,常规组不另服药。3组用药时间均为6周,观察3组患者术后1周(用药前)、术后7周及随访1年后的视力、视网膜电图变化和视网膜脱离复发情况。结果视力改善情况中药复方组优于益脉康组及常规组(P<0.01)。各组用药后及随访1年后与用药前比较暗适应及明适应a、b波振幅升高(P<0.01),中药复方组明适应a波、b波峰时缩短(P<0.01)。用药后及随访1年后,中药复方组与益脉康组及常规组比较,暗适应及明适应a、b波振幅升高(P<0.01),明适应a波峰时缩短(P<0.01)。中药复方组视网膜脱离复发率较其他两组降低,但差异无统计学意义(P>0.05)。结论益气养阴活血利水中药复方能够改善视网膜复位术后患者的视力,改善视网膜电图,从而改善患者视功能。

Objective To observe curative effects of Chinese medicine compound for tonifying qi, nourishing yin, promoting blood, and alleviating water retention （CMC-TQNYPBAWR） for patients after retinal detachment （RD） surgery. Methods Totally 786 patients after RD surgery were randomly assigned to three groups, CMC-TQNYPBAWR group （265 cases）, Yimaikang Tablets （YMKT） group （263 cases）, and routine treatment group （258 cases）. After RD surgery all patients received routine anti-inflammation and hemostasis therapy. Two weeks later patients in the CMC-TQNYPBAWR group took CMC-TQNYPBAWR and those in the YMKT group took YMKT. Patients in the routine treatment group took no additional drug. The therapeutic course for all was 6 weeks. The visual acuity, changes of electroretinogram and RD were observed in all patients of the 3 groups after post-surgery 1 week （before treatment）, post-surgery 7 weeks, and 1 year follow-up, respectively. Results l-he vision improvement was better in the CMC-TQNYPBAWR group than in the YMKT group and the routine treatment group （P 〈0.01 ）. Compared with before treatment, both a and b wave amplitude of dark and light adaptation significantly increased in each group after treatment and at post-surgery 1 year follow-ups （P 〈0.01 ）. Compared with before treatment, both the peaking time of a and b wave of light adaptation was statistically shortened in the CMC-TQNYPBAWR group （P 〈0.01 ）. Compared with the routine treatment group, both a and b wave amplitude of dark and light adaptation statistically increased in the CMC-TQNYPBAVMR group and the YMKT group after treatment and at post-surgery 1 year follow-ups （P 〈0. 01 ）. The peaking time of a wave of light adaptation was shortened （P 〈0.01 ）. The recurrence rate of RD was lower in CMC-TQNYPBAWR group than in the other two groups, but with no statistical difference （P 〉0.05）. Conclusion CMC-TQNYPBAWR could promote patients＇ vision after RD surgery and improve electroretinogram, thus ameliorating their visual function.